Antibody elimination by apheresis in living donor liver transplant recipients.
Antibody elimination by apheresis in living donor liver transplant recipients.
复制标题
通过血浆分离术消除活体肝移植受者体内的抗体。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
S. Satomi
中科院分区：
文献类型：
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作者：
N. Kawagishi;N. Ohkohchi;K. Fujimori;T. Orii;N. Koyamada;H. Kikuchi;S. Sekiguchi;S. Tsukamoto;T. Sato;S. Satomi
在本研究中，我们回顾了肝移植受者消除先前存在的抗同种异体抗体的适应症和疗效。3例ABO血型不合的患者在活体供肝移植(LDLTx)前行血浆置换和双滤血浆置换，滴度降至8以下。移植后3例同时行血浆置换，1例持续血液透析滤过，其中2例发生急性排斥反应。2例交叉配型阳性患者在移植前行血浆置换，T温滴度降至<2分，移植后无急性排斥反应。我们的结论是，在肝移植患者中，分离术对预防移植前预先存在的抗A和/或抗B抗体和抗供体特异性抗体引起的急性排斥反应是有效的，但对于移植后发生加速性体液排斥反应的患者则无效。
In the present study, we investigated retrospectively the indications and the efficacy of the elimination of preexisting antiallogeneic antibodies in liver transplant recipients. Three patients who were ABO blood type incompatible were subjected to plasmapheresis and double filtration plasmapheresis before the living donor liver transplantation (LDLTx), and the titers decreased to less than 8. After transplantation, plasmapheresis was also performed in 3 cases, and continuous hemodiafiltration in 1 case, and in 2 out of these 3 patients acute rejection was recognized. Two patients who were crossmatch positive were subjected to plasmapheresis before transplantation, and the T warm titers were reduced to less than Score 2. These 2 patients had no acute rejections after transplantation. We conclude that in liver transplant patients apheresis is effective to prevent acute rejection induced by preexisting anti-A and/or anti-B antibodies and anti-donor specific antibodies before transplantation, but it is not effective in a patient with accelerated humoral rejection occurring after transplantation.
A 和 B 同种抗原在正常和恶性固定人体组织中的单克隆抗体定位。
DOI：
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发表时间：
1984
期刊：
The American journal of pathology
影响因子：
--
作者：
Ernst,C;Thurin,J;Atkinson,B;Wurzel,H;Herlyn,M;Stromberg,N;Civin,C;Koprowski,H
通讯作者：
Koprowski,H