Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women
Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women
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DOI：
10.4238/2013.september.3.4
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发表时间：
2013-01-01
影响因子：
0.4
通讯作者：
Su, Y. X.
中科院分区：
文献类型：
--
作者：
Song, J. F.;Jing, Z. Z.;Su, Y. X.
骨质疏松症是一个重要的和常见的复杂的健康问题，特别是在绝经后妇女。其特征在于骨矿物质密度（BMD）降低和骨微结构恶化，从而增加骨折风险。骨保护素（OPG）基因被认为在骨质疏松症的发病机制中起重要作用。我们分析了399名中国绝经后妇女OPG基因的SNPs及其多态性与BMD的关系。在腰椎（L2-4）、股骨颈和全髋关节定量BMD。共和党2264 T>C和g.采用PCR-RFLP和DNA测序方法检测27676 A>C单核苷酸多态性。发现g与脊柱骨密度显着相关。27676A>C. AA基因型个体的脊柱骨密度值显著高于GA和AA基因型个体。任何SNP标记基因型和其他性状之间没有显着的关联。我们的结论是G。OPG基因27676 A>C影响脊柱BMD，C等位基因与中国绝经后妇女骨质疏松症风险增加相关。
Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs of the OPG gene and associations between these polymorphisms and BMD in 399 Chinese postmenopausal women. BMD was quantified at the lumbar spine (L2-4), femoral neck, and total hip. The g. 2264T>C and g. 27676A>C SNPs were detected by PCR-RFLP and DNA sequencing methods. A significant association with spine BMD was found for g. 27676A>C. The spine BMD value for subjects with genotype AA was significantly higher than those with genotypes GA and AA. No significant association was detected between any of the SNP marker genotypes and the other traits. We conclude that g. 27676A>C in the OPG gene affects spine BMD and that the C allele is associated with increased risk for osteoporosis in Chinese postmenopausal women.