Physical Activity and All-cause Mortality: An Updated Meta-analysis with Different Intensity Categories
Physical Activity and All-cause Mortality: An Updated Meta-analysis with Different Intensity Categories
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DOI：
10.1055/s-0028-1128150
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发表时间：
2009-03-01
影响因子：
2.5
通讯作者：
Knapp, G.
中科院分区：
文献类型：
--
作者：
Loellgen, H.;Boeckenhoff, A.;Knapp, G.
在一项荟萃分析中，我们调查了不同强度类别的体力活动对全因死亡率的影响。许多研究报告了定期体育活动对一级预防的积极影响。这项最近的荟萃分析分析了全因死亡率，特别参考了强度类别。在EMBASE、PUBMED和MEDLINE数据库（1990 - 2006）中进行了计算机系统文献检索，以获得关于体育休闲活动的前瞻性队列研究。38项研究得到确认和评价。本报告涉及根据标准问卷进行的3或4种不同强度的常规体力活动的研究。有一个显着的关联较低的全因死亡率为活跃的个人相比，久坐的人。对于三种活动类别（轻度、中度和高度活动）和多变量校正模型的研究，与轻度活动男性相比，高度活动男性的全因死亡风险降低22%（RR = 0.78; 95%CI：0.72至0.84）。对于女性，相对风险为0.69（95% CI：0.53至0.90）。我们在中度活动人群中观察到与轻度活动人群相似的结果（男性RR = 0.81，女性RR = 0.76）。这种活动与全因死亡率的相关性在老年受试者中相似且显著。与久坐者相比，较长时间的定期身体活动与活动受试者的全因死亡率降低密切相关。有一个剂量-反应曲线，特别是从久坐的受试者到轻度和中度运动的受试者，随着活动水平的进一步增加，只有轻微的额外减少。
In a meta-analysis we investigated the effect of physical activity with different intensity categories on all-cause mortality. Many Studies have reported positive effects of regular physical activity on primary prevention. This recent meta-analysis analyzed all-cause mortality with special reference to intensity categories. A computerized systematic literature search was performed in EMBASE, PUBMED, and MEDLINE data bases (1990-2006) for prospective cohort studies on physical leisure activity. Thirty-eight studies were identified and evaluated. The presentation refers to studies with 3 or 4 different intensities of regular physical activity according to a standard questionnaire. There was a significant association of lower all-cause mortality for active individuals compared with sedentary persons. For Studies with three activity categories (mildly, moderately, and highly active) and multivariate-adjusted models, highly active men had a 22% lower risk of all-cause mortality (RR=0.78; 95% CI: 0.72 to 0.84) compared to mildly active men. For women, the relative risk was 0.69 (95% CI: 0.53 to 0.90). We observed similar results in moderately active persons compared to mildly active individuals (RR=0.81 for men and RR=0.76 for women). This association of activity to all-cause mortality was similar and significant in older Subjects. Regular physical activity over longer time is strongly associated with a reduction in all-cause mortality in active subjects compared to sedentary persons. There is a dose-response curve especially from sedentary Subjects to those with mild and moderate exercise with only a minor additional reduction with further increase in activity level.