Association Between Sex Hormones and Adiposity: Qualitative Differences in Women and Men in the Multi-Ethnic Study of Atherosclerosis
Association Between Sex Hormones and Adiposity: Qualitative Differences in Women and Men in the Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1210/jc.2014-2934
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发表时间：
2015-04-01
影响因子：
5.8
通讯作者：
Golden, Sherita Hill
中科院分区：
文献类型：
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作者：
Mongraw-Chaffin, Morgana L.;Anderson, Cheryl A. M.;Golden, Sherita Hill
内容：性激素可能影响脂肪组织沉积，可能导致心血管疾病风险的性别差异。目的：我们假设性激素水平与内脏和皮下脂肪的相关性因性别而异。设计、设置和参与者：与会者来自多个-动脉粥样硬化的种族研究，基线时的性激素水平和访视2或3时计算机断层扫描的内脏和皮下脂肪测量值主要指标：采用多元线性回归分析性激素与肥胖的关系。结果：在调整后的模型中，雌二醇和内脏脂肪在两种性别中都有适度的显著正相关（女性内脏脂肪百分比差异对应1%激素差异[95%置信区间]，5.44 [1.82，9.09];男性，8.22 [0.61，16.18]）。在女性中，较高的生物可利用T与较高的内脏和皮下脂肪显著相关，而在男性中则相反（女性，14.38 [10.23，18.69];男性，-7.69 [-13.06，-1.00]）。在女性中，较高的脱氢表雄酮与较高的内脏脂肪相关（7.57 [1.71，13.88]），但在男性中不相关（-2.47 [-8.88，4.29]）。在男性和女性中，较高的SHBG与肥胖水平显著降低相关（女性，-24.42 [-28.11，-20.55];男性，-27.39 [-32.97，-21.34]）。有没有显着的相互作用，种族/民族或age.Conclusion：性激素显着相关的肥胖症，雄激素的协会不同的性别。这种异质性可能有助于解释性激素对心血管疾病性别差异的复杂性。
Context: Sex hormones may influence adipose tissue deposition, possibly contributing to sex disparities in cardiovascular disease risk.Objective: We hypothesized that associations of sex hormone levels with visceral and subcutaneous fat differ by sex.Design, Setting, and Participants: Participants were from the Multi-Ethnic Study of Atherosclerosis with sex hormone levels at baseline and visceral and subcutaneous fat measurements from computed tomography at visit 2 or 3 (n = 1835).Main Outcome Measures: Multivariable linear regression was used to investigate the relationships between sex hormones and adiposity. Testing for interaction by sex, race/ethnicity, and age was conducted.Results: In adjusted models, there was a modest significant positive association between estradiol and visceral fat in both sexes (percent difference in visceral fat for 1% difference in hormone [95% confidence interval] in women, 5.44 [1.82, 9.09]; and in men, 8.22 [0.61, 16.18]). Higher bioavailable T was significantly associated with higher visceral and subcutaneous fat in women and with the reverse in men (women, 14.38 [10.23, 18.69]; men, -7.69 [-13.06, -1.00]). Higher dehydroepiandrosterone was associated with higher visceral fat in women (7.57 [1.71, 13.88]), but not in men (-2.47 [-8.88, 4.29]). Higher SHBG was associated with significantly lower levels of adiposity in both sexes (women, -24.42 [-28.11, -20.55]; men, -27.39 [-32.97, -21.34]). There was no significant interaction by race/ethnicity or age.Conclusion: Sex hormones are significantly associated with adiposity, and the associations of androgens differ qualitatively by sex. This heterogeneity may help explain the complexity of the contribution of sex hormones to sex differences in cardiovascular disease.