Manganese-induced parkinsonism and Parkinson's disease
Manganese-induced parkinsonism and Parkinson's disease
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DOI：
10.1196/annals.1306.018
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Olanow, CW
中科院分区：
文献类型：
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作者：
Olanow, CW
长期以来，人们一直认为锰暴露会导致神经毒性和类似帕金森病（PD）的神经综合征。目前的证据表明，锰诱导的帕金森综合征可以从PD区分，因为它倾向于积累和损害苍白球和纹状体，而不是SNc。临床综合征、对左旋多巴的反应、MRI和PET的影像学研究以及病理特征都有助于区分这两种情况并建立正确的诊断。这在区分锰中毒所致帕金森综合征患者与偶然锰暴露的特发性PD患者时特别相关。
It has long been appreciated that manganese exposure can cause neurotoxicity and a neurologic syndrome that resembles Parkinson's disease (PD). Current evidence indicates that manganese-induced parkinsonism can be differentiated from PD because of its predilection to accumulate in and damage the pallidum and striatum rather than the SNc. The clinical syndrome, response to levodopa, imaging studies with MRI and PET, and pathologic features all help to distinguish these two conditions and permit the correct diagnosis to be established. This is of particular relevance in differentiating patients with parkinsonism due to manganese intoxication from patients with idiopathic PD who have incidental manganese exposure.