PHARMACOLOGIC CLOSURE OF PATENT DUCTUS-ARTERIOSUS IN PREMATURE-INFANT
PHARMACOLOGIC CLOSURE OF PATENT DUCTUS-ARTERIOSUS IN PREMATURE-INFANT
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DOI：
10.1056/nejm197609022951003
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发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
KIRKPATRICK, SE
中科院分区：
文献类型：
--
作者：
FRIEDMAN, WF;HIRSCHKLAU, MJ;KIRKPATRICK, SE
The prostaglandins affect smooth-muscle tone of the ductus arteriosus. Patent ductus often complicates the clinical course of prematurely born infants with respiratory-distress syndrome. In this study a single oral or rectal dose of a potent inhibitor of prostaglandin synthesis, indomethacin, was administered to 6 consecutive premature infants with the syndrome who would otherwise have undergone surgical ligation of the patent ductus. Within 24 h all the clinical symptoms and physical, echocardiographic and radiographic signs attributable to substantial left-to-right shunting through a patent ductus arteriosus dramatically and permanently disappeared. A transient reduction in renal function was observed in 2 infants in whom sustained ill-effects did not occur. The observation that constriction and closure of the patent ductus arteriosus may be induced pharmacologically raises important possibilities for the improved treatment of the respiratory-distress syndrome.
