One-carbon metabolism dietary factors and distal gastric cancer risk in chinese women.
One-carbon metabolism dietary factors and distal gastric cancer risk in chinese women.
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DOI：
10.1158/1055-9965.epi-14-0038
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Shrubsole MJ
中科院分区：
文献类型：
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作者：
Kweon SS;Shu XO;Xiang Y;Yang G;Ji BT;Li H;Gao YT;Zheng W;Shrubsole MJ
Previous studies on the association between one-carbon dietary factors and gastric cancer risk have been inconsistent. We investigated this association using data from a prospective study, the Shanghai Women’s Health Study (1997–2010), including 323 distal gastric cancer cases identified from 73,009 Chinese women. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazard regression after adjusting for confounders. Overall, no statistically significant association of gastric cancer was observed with dietary intake of folate, methionine, or B vitamins. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women with HR of 0.35 (95% CI: 0.17, 0.73), 0.48 (0.24, 0.97), 0.28 ( 0.12, 0.65), and 0.23 (0.07, 0.91), respectively, for the quintile 2 to 5 intake groups compared to the lowest quintile intake (p for trend=0.02]. Among premenopausal women, highest intake of folate was associated with increased gastric cancer risk (HR: 2.62; 95% CI: 1.04, 6.59). There were no statistically significant associations observed among postmenopausal women. These results suggest dietary factors involved in one-carbon metabolism are associated with gastric cancer risk among premenopausal women. Riboflavin may be a protective factor and folate may be a risk factor for premenopausal gastric cancer.
