CUTANEOUS LOCALIZATION OF THE MEMBRANE ATTACK COMPLEX IN DISCOID AND SYSTEMIC LUPUS-ERYTHEMATOSUS
CUTANEOUS LOCALIZATION OF THE MEMBRANE ATTACK COMPLEX IN DISCOID AND SYSTEMIC LUPUS-ERYTHEMATOSUS
复制标题
DOI：
10.1056/nejm198202043060503
复制
发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
KOFFLER, D
中科院分区：
文献类型：
--
作者：
BIESECKER, G;LAVIN, L;KOFFLER, D
3例盘状红斑狼疮和6例系统性红斑狼疮的皮损活检标本含有膜攻击复合体，包括补体C5b、C6、C7、C8和C9，以及真皮-表皮交界处的免疫复合体。这些区域的基底上皮细胞呈空泡化和水肿状，真皮内有炎性浸润物。在29例盘状红斑狼疮或系统性红斑狼疮患者外观正常的皮肤标本中，19例仅在真皮-表皮交界处显示免疫复合体，无膜攻击复合体。其他10例标本均来自无皮肤受累的患者，均未显示免疫复合体或膜攻击复合体。皮损内的免疫复合体显然选择性地产生膜攻击复合体的组装，而膜攻击复合体介导膜损伤。可能需要免疫复合体和辅因子的协同作用来激活易受组织损伤的皮肤区域的补体。
Biopsy specimens of skin lesions from 3 patients with discoid lupus erythematosus and 6 patients with systemic lupus erythematosus contained the membrane attack complex, which comprises C5b [complement component 5b], C6, C7, C8 and C9, and immune complexes at the dermal-epidermal junction. The basilar epithelium in these areas was vacuolated and edematous, and the dermis contained an inflammatory infiltrate. Of 29 specimens of normal-appearing skin from patients with discoid or systemic lupus erythematosus, 19 showed only immune complexes at the derma-epidermal junction, without the membrane attack complex. The other 10 specimens, all from patients without cutaneous involvement, showed neither immune complexes nor membrane attack complexes. Immune complexes within skin lesions apparently selectively generate the assembly of the membrane attack complex, which mediates membrane injury. A synergistic interaction of immune complexes and cofactors may be required to activate complement in areas of skin that are predisposed to tissue injury.