Delivery nanoplatforms based on dynamic covalent chemistry
Delivery nanoplatforms based on dynamic covalent chemistry
复制标题
基于动态共价化学的递送纳米平台
DOI：
10.1039/d1cc02246f
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发表时间：
2021-06-10
影响因子：
4.9
通讯作者：
Tang, Bo
中科院分区：
文献类型：
--
作者：
Lu, Fei;Zhang, Huiwen;Tang, Bo
作为限制药物和生物制剂潜在作用的最重要因素，基于动态共价化学的纳米平台已被证明是有希望的候选者，以满足整个递送过程中的全部要求，凭借其显着的特性，如适应性，刺激响应性，特异性，可逆性和可行性。这篇文章总结了基于动态共价键的纳米平台的最新进展，其具有改进的递送效率和治疗性能。此外，还讨论了该领域的主要挑战和前景。我们期望这篇专题文章将为进一步开发基于动态共价键的纳米平台提供有价值和系统的参考。
As a paramount factor to restrict the potential action of drugs and biologics, nanoplatforms based on dynamic covalent chemistry have been demonstrated as promising candidates to fulfill the full requirements during the whole delivery process by the virtue of their remarkable features such as adaptiveness, stimuli-responsiveness, specificity, reversibility and feasibility. This contribution summarizes the latest progress in dynamic covalent bond-based nanoplatforms with improved delivery efficiency and therapeutic performance. In addition, major challenges and perspectives in this field are also discussed. We expect that this feature article will provide a valuable and systematic reference for the further development of dynamic covalent bond-based nanoplatforms.