Partial Least Squares Analysis of Alzheimer's Disease Biomarkers, Modifiable Health Variables, and Cognition in Older Adults with Mild Cognitive Impairment.
Partial Least Squares Analysis of Alzheimer's Disease Biomarkers, Modifiable Health Variables, and Cognition in Older Adults with Mild Cognitive Impairment.
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DOI：
10.1017/s1355617721001041
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发表时间：
2022-09
影响因子：
2.6
通讯作者：
Hayes, Scott M.
中科院分区：
文献类型：
--
作者：
Stark, Jessica;Palombo, Daniela J.;Hayes, Jasmeet P.;Hiersche, Kelly J.;Hasselbach, Alexander N.;Hayes, Scott M.
在一组患有轻度认知障碍(MCI)的老年人中，确定可修改的身体和健康变量、阿尔茨海默病(AD)生物标记物和认知功能之间的新关联。来自阿尔茨海默病神经成像计划的154名MCI参与者(平均年龄=74.1岁)对心脏代谢风险、压力、炎症、神经营养/生长因子、AD和认知进行了评估。偏最小二乘分析被用来检验这些生理变量和认知之间的关系。潜在变量1揭示了AD生物标志物、神经营养/生长因子、教育和压力的独特组合，它们与认知功能的特定领域显著相关，包括情景记忆、执行功能、处理速度和语言，代表了数据中跨区组协方差的45.2%。年龄、体重指数和利用基本注意力或发病前智商的指标并不显著。我们的数据驱动分析强调了与AD病理、神经保护和神经可塑性相关的指标之间的重要关系，主要是与利用情景记忆、执行功能、处理速度和语言流利性的任务之间的关系，而不是不需要精神操纵的更基本的任务(基本注意力和词汇)。这些数据还表明，在患有MCI的老年人中，生物学指标与情节记忆、执行功能和处理速度的相关性比年龄更强。
To identify novel associations between modifiable physical and health variables, Alzheimer’s disease (AD) biomarkers, and cognitive function in a cohort of older adults with Mild Cognitive Impairment (MCI). Metrics of cardiometabolic risk, stress, inflammation, neurotrophic/growth factors, AD, and cognition were assessed in 154 MCI participants (Mean age = 74.1 years) from the Alzheimer’s Disease Neuroimaging Initiative. Partial Least Squares analysis was employed to examine associations among these physiological variables and cognition. Latent variable 1 revealed a unique combination of AD biomarkers, neurotrophic/growth factors, education, and stress that were significantly associated with specific domains of cognitive function, including episodic memory, executive function, processing speed, and language, representing 45.2% of the cross-block covariance in the data. Age, body mass index, and metrics tapping basic attention or premorbid IQ were not significant. Our data-driven analysis highlights the significant relationships between metrics associated with AD pathology, neuroprotection, and neuroplasticity, primarily with tasks tapping episodic memory, executive function, processing speed, and verbal fluency rather than more basic tasks that do not require mental manipulation (basic attention and vocabulary). These data also indicate that biological metrics are more strongly associated with episodic memory, executive function, and processing speed than chronological age in older adults with MCI.