DENERVATION OF PRIMARY OLFACTORY PATHWAY IN MICE .5. LONG-TERM EFFECT OF INTRANASAL ZNSO4 IRRIGATION ON BEHAVIOR, BIOCHEMISTRY AND MORPHOLOGY
DENERVATION OF PRIMARY OLFACTORY PATHWAY IN MICE .5. LONG-TERM EFFECT OF INTRANASAL ZNSO4 IRRIGATION ON BEHAVIOR, BIOCHEMISTRY AND MORPHOLOGY
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DOI：
10.1016/0006-8993(78)90460-2
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发表时间：
1978-01-01
期刊：
影响因子：
2.9
通讯作者：
MARGOLIS, FL
中科院分区：
文献类型：
--
作者：
HARDING, JW;GETCHELL, TV;MARGOLIS, FL
Intranasal irrigation of mice with 0.17 M ZnSO4 solution resulted in the immediate and total loss of the ability to find a buried food pellet. This anosmia persisted for 6 wk in at least 80% of the treated mice and for 4 mo. in half the animals. This marked behavioral effect was matched by a long-term reduction of the levels of carnosine synthesis and transport in the primary olfactory pathway. These biochemical parameters were virtually undetectable at 2 wk after treatment and even at 1 yr after treatment did not exceed 5-10% of average control values. Light microscopic observations of tissues of the primary olfactory pathway at various times after treatment were consistent with these observations and indicated a substantial destruction of the olfactory epithelium with subsequent atrophy of the olfactory bulb. At very long intervals after treatment some receptor regeneration was apparent with accompanying reinnervation of the olfactory bulb. Estimates from microscopy and biochemistry suggested that much less than 10% of the normal complement of functioning receptor cells was adequate to give apparently normal food-finding behavior.
