Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDMS and IDDM8
Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDMS and IDDM8
复制标题
DOI：
10.1093/hmg/5.5.693
复制
发表时间：
1996-05-01
影响因子：
3.5
通讯作者：
She, JX
中科院分区：
文献类型：
--
作者：
Luo, DF;Buzzetti, R;She, JX
先前的全基因组定位研究为胰岛素依赖型糖尿病（IDDM）的几个新的易感基因位点提供了提示性连锁证据;然而，证据不足以证实这些基因的存在，我们分析了265个患有IDDM的高加索家庭，并报告了第一个符合三个易感基因连锁标准的证据，对于染色体11 q13上的IDDM 4、6 q25上的IDDM 5和6 q27上的IDDM 8，在我们的数据集中的最大LOD得分（MLS）分别为3.9、4.5和3.6，并且对于我们的数据结合来自文献的非重叠数据，分别为5.0、4.6和5.0。我们不能确定IDDM 3在15 q26和IDDM 7在2 q31-q33之间的连锁，也不能确定D2 S152和IDDM 7之间的连锁不平衡。
Previous genome-wide mapping studies have provided suggestive linkage evidence for several novel susceptibility loci responsible for insulin-dependent diabetes mellitus (IDDM); however, the evidence was not sufficient to confirm the existence of these genes, We analyzed 265 Caucasian families with IDDM and report the first evidence that meets the standard for confirmed linkage for three susceptibility loci, The maximum LOD scores (MLS) were 3.9, 4.5 and 3.6 in our data set, and 5.0, 4.6 and 5.0 for our data combined with non-overlapping data from the literature, for IDDM4 on chromosome 11q13, IDDM5 on 6q25, and IDDM8 on 6q27, respectively, However, we could not confirm linkage for IDDM3 on 15q26 and IDDM7 on 2q31-q33, or linkage disequilibrium between D2S152 and IDDM7.