The spatial characteristics of the painful thermal grill illusion
The spatial characteristics of the painful thermal grill illusion
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DOI：
10.1016/j.pain.2008.02.012
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发表时间：
2008-09-15
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, Lars
中科院分区：
文献类型：
--
作者：
Defrin, Ruth;Benstein-Sheraizin, Anat;Arendt-Nielsen, Lars
冷刺激和暖刺激相互交错，可能会产生一种自相矛盾的烧灼感，称为“热烧烤错觉”。关于烧烤错觉的研究在其质量和强度方面产生了相互矛盾的结果，这反过来又导致了关于其潜在机制的争议。一些争议可能是因为用绝对温度测试错觉，从而忽略了受试者之间温度敏感度的变化。因此，我们的目标是测量痛苦烧烤错觉(PGI)的个体阈值。另一个目标是通过在空间上分离变冷和变暖刺激来首次测量PGI的空间边界。受试者(男10人，女15人)在前臂分别用9和18 cm(2)刺激探头测量热痛(HPT)和冷痛阈值(CPT)。受试者还接受了痛阈值(PT)的测量，其中一个冷却探头和一个加热探头(各9 cm(2))同时激活，并相隔0-30 cm(围绕一个或两个皮肤体的距离)。同时的冷和热刺激在所有分离距离都会产生灼痛。PT(与26℃和38℃相似)分别显著低于CPT和HPT，除30 cm处PT向CPT和HPT升高外，其余距离均相对固定。结论：无伤害性冷热刺激可在皮肤体内和皮小体之间在空间上相加，并可能诱发PGI，非伤害性通道整合到二、三级伤害性感觉神经元上，进而引起冷热混合的独特痛性灼伤。(C)国际疼痛研究协会。爱思唯尔出版公司版权所有。
Interlaced cold and warm stimuli may induce a paradoxical burning sensation termed the "thermal grill illusion". Studies on the grill illusion have yielded contradictory results regarding its quality and intensity, which in turn led to controversies concerning the underlying mechanism. Some controversies may result from testing the illusion with absolute temperatures thereby disregarding inter-subjects' variation in temperature sensitivity. Therefore, our aim was to measure the individual threshold of the painful grill illusion (PGI). Another aim was to measure, here for the first time, the spatial boundaries of the PGI by spatially separating between the cooling and warming stimuli. Subjects (10 males, 15 females) underwent measurements of heat-pain (HPT) and cold-pain thresholds (CPT) with 9 and 18 cm(2) stimulating probes, on the forearm. Subjects also underwent measurement of pain threshold (PT), with one cooling and one heating probe (9 cm(2) each) activated Simultaneously, and separated by 0-30 cm (distances encompassing one or two dermatomes). Simultaneous cold and warm stimuli produced burning pain at all separation distances. PT (similar to 26 and 38 degrees C) was significantly lower than CPT and HPT, respectively, and was relatively fixed across all distances except for 30 cm at which PT increased towards CPT and HPT values. Gender did not affect the PGI In conclusion, innocuous cold and warm stimuli can spatially summate, both within and between dermatomes and evoke a PGI Possibly, non-nociceptive channels integrate onto 2nd or 3rd order nociceptive neurons which in turn induce a unique painful burning resulting from the blend of cold and warm sensations. (C) International Association for the Study of Pain. Published by Elsevier B.V All rights reserved.