The impact of polyol-containing chewing gums on dental caries A systematic review of original randomized controlled trials and observational studies
The impact of polyol-containing chewing gums on dental caries A systematic review of original randomized controlled trials and observational studies
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DOI：
10.14219/jada.archive.2008.0102
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发表时间：
2008-12-01
影响因子：
3.9
通讯作者：
Jadad, Alejandro R.
中科院分区：
文献类型：
--
作者：
Deshpande, Amol;Jadad, Alejandro R.
背景作者对旨在评估含多元醇口香糖与不含口香糖的口香糖对龋齿影响的原始研究进行了系统回顾。作者检索了截至2008年5月的MEDLINE、科克伦图书馆和谷歌学术，以识别比较含多元醇咀嚼胶与不含咀嚼胶的同行评审文章。作者通过共识提取了研究特征、增量龋齿数据和质量。研究中预防分数（PF）的数据汇总。19篇文章的结果显示，木糖醇、木糖醇-山梨醇混合物和山梨醇的使用与平均PIT（95%置信区间）的相关性分别为58.66%（35.42-81.90）、52.82%（39.64-66.00）和20.01%（12.74-27.27）。对于山梨醇-甘露醇混合物，其为10.71%（-20.50-41.93），无统计学意义。敏感性分析证实了结果的稳健性。临床意义。尽管存在研究空白，特别是在最佳剂量和相对多元醇功效方面，但研究证据支持将含多元醇的口香糖作为正常口腔卫生的一部分来预防龋齿。
Background. The authors conducted a systematic review of original studies that was designed to assess the impact of polyol-containing chewing gum on dental caries compared with the effect with no chewing gum.Review Methods. The authors searched MEDLINE, The Cochrane Library and Google Scholar up to May 2008 to identify peer-reviewed articles that compared polyol-containing chewing gum with no chewing gum. The authors extracted study characteristics, data on incremental dental caries and quality by consensus. Data on prevented fraction (PF) were pooled across studies.Results. The results of 19 articles with data from 14 study populations showed that the use of xylitol, xylitol-sorbitol blend and sorbitol were associated with mean PIT (95 percent confidence interval) of 58.66 percent (35.42-81.90), 52.82 percent (39.64-66.00) and 20.01 percent (12.74-27.27), respectively. For the sorbitol-mannitol blend, it was 10.71 percent (-20.50-41.93), which was not statistically significant. Sensitivity analyses confirmed the robustness of the findings.Clinical Implications. Although research gaps exist, particularly on optimal dosing and relative polyol efficacy, research evidence supports using polyol-containing chewing gum as part of normal oral hygiene to prevent dental caries.