Roots of Zea mays L.: As a Potential Source to Treat Sodium Oxalate-Induced Renal Cell Injury.
Roots of Zea mays L.: As a Potential Source to Treat Sodium Oxalate-Induced Renal Cell Injury.
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DOI：
10.1021/acs.jafc.3c05248
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发表时间：
2023-11
影响因子：
6.1
通讯作者：
Yunqiang Zhang;Jianyu Liu;Kehua Jiang;Yu Duan;Yiling Zhang;Xue Qiu;Yanhua Fan;Jianguo Zhu;Yongnan Xu
中科院分区：
文献类型：
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作者：
Yunqiang Zhang;Jianyu Liu;Kehua Jiang;Yu Duan;Yiling Zhang;Xue Qiu;Yanhua Fan;Jianguo Zhu;Yongnan Xu
Zea mays L.是禾本科的一年生草，被称为谷类作物之一。其副产品具有重要的药用价值。在我国部分地区，Z.玉米根（RM）用于治疗肾结石，但没有研究报告。在本研究中，我们使用生物测定指导的分离方法，得到5个新的木脂素（1-5）以及15个已知的成分，其中8-15和17-20首次从该属中鉴定。评价各组分和所有组分抑制琥珀酸钠诱导的人近端肾小管HK-2细胞损伤的能力。组分50 W和化合物3、4和11表现出最强的活性。进一步的研究表明，这些潜在的药物抑制LDH的释放，降低MDA和H2 O2的浓度，并增加SOD 2的水平。这些结果表明，RM是一种具有开发利用价值的农作物废弃物，可用于肾结石药物研究。
Zea mays L. is an annual grass of the Gramineae family and is known as one of the cereal crops. Its by-products exhibited significant medicinal properties. In some regions of China, water extracts of Z. mays roots (RM) are utilized to treat kidney stones, but no research has been reported. In our present study, a bioassay-guided isolation method was used to yield five new lignans (1-5) as well as 15 known components, among which 8-15 and 17-20 were first identified from the genus. The fractions and all components were evaluated for their abilities to inhibit sodium oxalate-induced injury to human proximal tubular HK-2 cells. Fraction 50W and compounds 3, 4, and 11 exhibited the most potent activities. Further investigation indicated that these potential agents inhibited the LDH release, decreased the MDA and H2O2 concentrations, and increased the level of SOD2 in HK-2 cells. These results indicated that RM is a promising and valuable crop waste for further development and utilization in nephrolithiasis pharmaceutical research.