Thymopoiesis independent of common lymphoid progenitors
Thymopoiesis independent of common lymphoid progenitors
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DOI：
10.1038/ni878
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发表时间：
2003-02-01
影响因子：
30.5
通讯作者：
Bhandoola, A
中科院分区：
文献类型：
--
作者：
Allman, D;Sambandam, A;Bhandoola, A
胸腺中的早期T谱系祖细胞（ETPs）被认为是由骨髓中的共同淋巴样祖细胞（CLPs）发展而来的。我们比较了小鼠胸腺etp和BM clp，发现它们在几个方面有所不同。胸腺ETPs对白细胞介素7 （IL-7）没有反应，产生的B系后代具有延迟动力学，而BM CLPs对IL-7有反应，迅速产生B细胞。与BM CLPs相比，ETPs持续产生T系后代的时间更长。对ikaros缺陷小鼠的分析显示，胸腺ETPs的频率接近正常，但BM CLPs的数量未检测到。我们得出结论，etp可以通过与clp无关的途径发展。
Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in mice and found that they differed in several respects. Thymic ETPs were not interleukin 7 (IL-7)-responsive and generated B lineage progeny with delayed kinetics, whereas BM CLPs were IL-7-responsive and rapidly generated B cells. ETPs sustained production of T lineage progeny for longer periods of time than BM CLPs. Analysis of Ikaros-deficient mice that exhibit ongoing thymopoiesis without B lymphopoeisis revealed near-normal frequencies of thymic ETPs, yet undetectable numbers of BM CLPs. We conclude that ETPs can develop via a CLP-independent pathway.