Nonviral vectors: we have come a long way.
Nonviral vectors: we have come a long way.
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非病毒载体：我们已经走了很长的路。
DOI：
10.1016/b978-0-12-800148-6.00001-8
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发表时间：
2014
影响因子：
--
通讯作者：
Huang L
中科院分区：
文献类型：
--
作者：
Goodwin T;Huang L
基因疗法曾经被认为是医学的未来，目前已经达到指数增长的开始阶段。目前正在通过各种基因传递载体在临床试验中研究和治疗许多类型的疾病。未来似乎已经来临，基因疗法才刚刚开始彻底改变患者的治疗方式。然而，尽管这些正在进行的治疗和临床试验很有希望，但为了继续这种积极的增长，还有更多的障碍和挑战需要解决和理解。我们应该扩大对这些具有挑战性的因素（例如基因摄取和表达）的了解，以改进现有的递送系统。本章将简要概述用于基因治疗的非病毒载体领域的最新进展，并指出一些有助于我们今天所知的非病毒基因治疗的非凡发展的新型载体。
Gene therapy, once thought to be the future of medicine, has reached the beginning stages of exponential growth. Many types of diseases are now being studied and treated in clinical trials through various gene delivery vectors. It appears that the future is here, and gene therapy is just beginning to revolutionize the way patients are treated. However, as promising as these ongoing treatments and clinical trials are, there are many more barriers and challenges that need to be addressed and understood in order to continue this positive growth. Our knowledge of these challenging factors such as gene uptake and expression should be expanded in order to improve existing delivery systems. This chapter will provide a brief overview on recent advances in the field of nonviral vectors for gene therapy as well as point out some novel vectors that have assisted in the extraordinary growth of nonviral gene therapy as we know it today.