THE ROLE OF C-MYC IN CELL-GROWTH
THE ROLE OF C-MYC IN CELL-GROWTH
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DOI：
10.1016/s0959-437x(05)80339-9
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发表时间：
1993-02-01
影响因子：
4
通讯作者：
LITTLEWOOD, TD
中科院分区：
文献类型：
--
作者：
EVAN, GI;LITTLEWOOD, TD
最近的实验已经证实，c-myc癌基因编码一种序列特异性的DNA结合蛋白，该蛋白与特定的细胞内伙伴Max相互作用，并可能通过转录调节来体现其作用。此外，c-myc表达的生物学功能不仅包括转化和有丝分裂，还包括细胞死亡。
Recent experiments have established that the c-myc oncogene encodes a sequence-specific DNA-binding protein that interacts with a specific intracellular partner, Max, and probably manifests its effects through transcriptional modulation. In addition, the range of biological functions attributed to expression of c-myc has grown to include not only transformation and mitogenesis but also cell death.