Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging.
Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging.
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DOI：
10.18632/oncotarget.24729
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发表时间：
2018-03-30
期刊：
影响因子：
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通讯作者：
Neri LM
中科院分区：
文献类型：
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作者：
Simioni C;Zauli G;Martelli AM;Vitale M;Sacchetti G;Gonelli A;Neri LM
体育锻炼被认为是适当生活方式的有益因素之一，如今被视为健康不可或缺的因素，能够降低心血管、内分泌和骨骼肌肉器官疾病、免疫系统疾病和潜在肿瘤发病的风险。适度和有计划的体育锻炼经常被报道在成年和老龄化中都有治疗作用，因为能够促进健康。定期运动可以消除自由基造成的负面影响，并提供许多健康益处，包括降低全因死亡率、骨骼肌减少症、慢性疾病和老年人过早死亡的风险。然而，物理性能也被称为诱导氧化应激，炎症和肌肉疲劳。已经进行了许多努力来鉴定微量营养素和天然化合物，也称为营养品，能够预防或减轻运动引起的氧化应激和炎症。这篇综述的目的是讨论从持续的身体活动中获得的益处，以及通过摄入抗氧化化合物来保护身体免受氧化应激。重点介绍了槲皮素、白藜芦醇和姜黄素三种天然抗氧化剂。将描述它们的性质和活性，以及它们对身体活动和衰老的益处，预计这些益处将随着时间的推移而增加，并且可以从持续的锻炼活动中获得有利的益处。
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.