Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model.
Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model.
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甲状旁腺激素和唑来膦酸通过促进去卵巢大鼠模型假体周围骨结构和强度来预防颗粒磨损引起的植入物松动
DOI：
10.3389/fendo.2022.871380
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发表时间：
2022
影响因子：
5.2
通讯作者：
Wu, Haobo
中科院分区：
文献类型：
--
作者：
Zhou, Chenhe;Wang, Yangxin;Meng, Jiahong;Yao, Minjun;Xu, Huikang;Wang, Cong;Bi, Fanggang;Zhu, Hanxiao;Yang, Guang;Shi, Mingmin;Yan, Shigui;Wu, Haobo
植入物产生的颗粒磨损被认为是导致植入物松动的主要原因，骨质疏松患者更容易发生松动。甲状旁腺激素（PTH）或唑来膦酸（ZOL）单药治疗已被证明可有效预防早期假体周围骨质溶解，而PTH和ZOL联合治疗对后路腰椎融合和废用性骨质减少的治疗具有有益作用。然而，迄今为止，PTH和ZOL尚未被批准用于临床治疗植入物松动。在这项研究中，我们探讨了单独或联合使用PTH和ZOL对骨质疏松症大鼠模型中种植体松动的影响。切除卵巢12周后，建立股骨颗粒诱导假体周围骨溶解模型。在处死前再使用溶剂、PTH（每周5天）、ZOL（每周100 mg/kg）或联合治疗6周，然后进行显微CT、组织学、机械测试和骨转换检查。PTH单药治疗或PTH与ZOL联合治疗通过提高假体周围骨量和抑制假膜形成对维持种植体稳定性产生保护作用。此外，当PTH与ZOL组合时观察到累加效应，导致比PTH单一疗法更好的固定强度、更高的假体周围骨量和更少的假膜。综上所述，我们的研究结果表明，PTH和ZOL的联合治疗可能是一种有前途的方法，用于干预骨质疏松症患者的早期种植体松动。
Implant-generated particle wears are considered as the major cause for the induction of implant loosening, which is more susceptible to patients with osteoporosis. Monotherapy with parathyroid hormone (PTH) or zoledronate acid (ZOL) has been proven efficient for preventing early-stage periprosthetic osteolysis, while the combination therapy with PTH and ZOL has exerted beneficial effects on the treatment of posterior lumbar vertebral fusion and disuse osteopenia. However, PTH and ZOL still have not been licensed for the treatment of implant loosening to date clinically. In this study, we have explored the effect of single or combined administration with PTH and ZOL on implant loosening in a rat model of osteoporosis. After 12 weeks of ovariectomized surgery, a femoral particle-induced periprosthetic osteolysis model was established. Vehicle, PTH (5 days per week), ZOL (100 mg/kg per week), or combination therapy was utilized for another 6 weeks before sacrifice, followed by micro-CT, histology, mechanical testing, and bone turnover examination. PTH monotherapy or combined PTH with ZOL exerted a protective effect on maintaining implant stability by elevating periprosthetic bone mass and inhibiting pseudomembrane formation. Moreover, an additive effect was observed when combining PTH with ZOL, resulting in better fixation strength, higher periprosthetic bone mass, and less pseudomembrane than PTH monotherapy. Taken together, our results suggested that a combination therapy of PTH and ZOL might be a promising approach for the intervention of early-stage implant loosening in patients with osteoporosis.
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影响因子：
3.7
作者：
Bi F;Shi Z;Zhou C;Liu A;Shen Y;Yan S
通讯作者：
Yan S
影响因子：
4.6
作者：
Athanasou NA
通讯作者：
Athanasou NA
影响因子：
158.5
作者：
Finkelstein, JS;Hayes, A;Neer, RM
通讯作者：
Neer, RM
影响因子：
14
作者：
Granchi, D;Amato, I;Giunti, A
通讯作者：
Giunti, A
影响因子：
4.2
作者：
Khatod, Monti;Inacio, Maria C. S.;Namba, Robert S.
通讯作者：
Namba, Robert S.