COMPLEMENT-DERIVED LEUKOTACTIC FACTORS IN PATHOLOGICAL FLUIDS
COMPLEMENT-DERIVED LEUKOTACTIC FACTORS IN PATHOLOGICAL FLUIDS
复制标题
病理液体中补体衍生的白细胞趋化因子
DOI：
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发表时间：
1971
影响因子：
15.3
通讯作者：
P. Ward
中科院分区：
文献类型：
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作者：
P. Ward
源自补体序列的趋白细胞因子由C5相关产物组成，包括小裂解产物和较高分子量复合物（C567）。还描述了一种具有白细胞活性的裂解产物（低分子量）。在两种情况下发现了C5相关因子：免疫性血管炎的可溶性组织提取物和类风湿性关节炎患者的滑液。C3相关产物已在炎性、非类风湿性关节炎患者的滑液和实验性梗死心肌提取物中发现。这些因子的存在可能与细胞渗出物的急性炎症性质有因果关系。
Leukotactic factors derived from the complement sequence consist of C5-related products, including the small cleavage product and the higher molecular weight complex (C567). A leukotactically active cleavage product (of low molecular weight) has also been described. The C5-related factors have been found in two conditions: soluble tissue extracts of immunologic vasculitis and in synovial fluids from patients with rheumatoid arthritis. The C3-related product has been found in synovial fluids from patients with inflammatory, nonrheumatoid arthritis and in extracts of experimentally infarcted myocardium. The presence of these factors may be causally related to the acute inflammatory nature of the cellular exudates.