Cell-cell communication via ciliary extracellular vesicles: clues from model systems.
Cell-cell communication via ciliary extracellular vesicles: clues from model systems.
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DOI：
10.1042/ebc20170085
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发表时间：
2018-05-15
影响因子：
6.4
通讯作者：
Barr MM
中科院分区：
文献类型：
--
作者：
Wang J;Barr MM
在这篇简短的综述中，我们将重点介绍纤毛细胞外囊泡（EVs）的独特性。特别是，我们将回顾已经了解到的关于模式生物纤毛产生的电动汽车。包括衣单胞菌、秀丽隐杆线虫和小鼠在内的模型系统揭示了纤毛和鞭毛的基本生物学，并为理解纤毛和鞭毛在人类发育、健康和疾病中的作用提供了一个范例。同样，我们提出，从模型系统中了解到的关于纤毛EV生物发生和功能的一般原则可以为探索纤毛EV在人类发育、健康和疾病中的作用提供框架。
In this short review, we will focus on the uniqueness of ciliary extracellular vesicles (EVs). In particular, we will review what has been learned regarding EVs produced by cilia of model organisms. Model systems including Chlamydomonas, C. elegans, and mouse revealed the fundamental biology of cilia and flagella and provide a paradigm to understand the roles of cilia and flagella in human development, health, and disease. Likewise, we propose that general principles learned from model systems regarding ciliary EV biogenesis and functions may provide a framework to explore the roles of ciliary EVs in human development, health, and disease.