Reproductive history and breast cancer survival: a prospective patient cohort study in Japan
Reproductive history and breast cancer survival: a prospective patient cohort study in Japan
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DOI：
10.1007/s12282-019-00972-5
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发表时间：
2019-11-01
期刊：
影响因子：
4
通讯作者：
Kakugawa, Yoichiro
中科院分区：
文献类型：
--
作者：
Minami, Yuko;Nishino, Yoshikazu;Kakugawa, Yoichiro
生殖因素可能影响乳腺癌的进展和患者的生存；然而，证据有限。方法分析1997-2013年在日本某医院诊断的1468例乳腺癌患者的生殖因素与肿瘤特征和患者生存的关系。这些患者被跟踪到2016年。在8.6年的中位随访期间，记录了272例全因乳腺癌死亡和199例乳腺癌死亡。结果在病例对比中，初潮年龄较晚与晚期肿瘤呈负相关。未生育患者多为受体阳性[雌激素受体(ER)+或孕激素受体(PR)+]肿瘤。相反，包括肿瘤特征调整在内的Cox比例风险模型显示，胎次数与患者整体全因死亡风险呈u型关系[未产者的风险比（HR）为2.10,2胎为1.28,1胎= 3胎为1.50]。根据激素受体，ER-和pr -癌患者的月经初潮年龄较晚和最后分娩年龄较晚与全因死亡风险呈正相关(月经初潮，HR = 2.18, bb0 = 15 vs = 35 vs。
Background Reproductive factors may influence breast cancer progression and patient survival; however, evidence has been limited.Methods The associations of reproductive factors with tumor characteristics and patient survival were analyzed among 1468 breast cancer patients diagnosed during 1997-2013 at a single institute in Japan. The patients were followed until 2016. During a median follow-up period of 8.6 years, 272 all-cause and 199 breast cancer deaths were documented.Results In case-case comparisons, later age at menarche was inversely associated with advanced tumors. Nulliparous patients tended to have receptor-positive [estrogen receptor (ER)+or progesterone receptor (PR)+] tumors. Conversely, the Cox proportional-hazards model including adjustment for tumor characteristics revealed U-shaped relationship between parity number and the risk of all-cause death among the patients overall [hazard ratio (HR) = 2.10 for nulliparous, 1.28 for 2, and 1.50 for >= 3 vs. one child]. According to hormone receptor, later age at menarche and later age at last birth were positively associated with the risk of all-cause death among patients with ER- and PR-cancer (menarche, HR = 2.18 for >= 15 vs. = 35 vs.