Immune senescence and cancer in elderly patients: Results from an exploratory study
Immune senescence and cancer in elderly patients: Results from an exploratory study
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DOI：
10.1016/j.exger.2013.09.011
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发表时间：
2013-12-01
影响因子：
3.9
通讯作者：
Zagonel, Vittorina
中科院分区：
文献类型：
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作者：
Falci, Cristina;Gianesin, Ketty;Zagonel, Vittorina
背景：免疫衰老的挑战从未在老年癌症患者中得到解决。本研究比较了胸腺输出和外周血端粒长度在>= 70岁的癌症patients.Patients和方法：52名老年癌症患者和39名年龄匹配的对照组没有个人癌症史。所有患者均接受综合老年评估（CGA），从中计算多维预后指数（MPI）评分。用流式细胞术检测外周血初发和近期胸腺移出（RTE）的CD 4（+）和CD 8（+）细胞。结果：恶性肿瘤患者外周血CD 8 + nave和CD 8（+）RTE细胞百分比及TREC水平均显著低于对照组（分别为p=0.003，p=0.004，p=0.031）。癌症患者外周血细胞中的端粒长度显著短于对照组（p=0.046），并且与患者的年龄无关，而与对照组相关（r=-0.354，p =0.031）。短端粒（
Background: The challenge of immune senescence has never been addressed in elderly cancer patients. This study compares the thymic output and peripheral blood telomere length in >= 70 year old cancer patients.Patients and methods: Fifty-two elderly cancer patients and 39 age-matched controls without personal history of cancer were enrolled. All patients underwent a Comprehensive Geriatric Assessment (CGA), from which a multidimensional prognostic index (MPI) score was calculated. Peripheral blood samples were studied for nave and recent thymic emigrant (RTE) CD4(+) and CD8(+) cells by flow cytometry. T-cell receptor rearrangement excision circle (TREC) levels, telomere length and telomerase activity in peripheral blood cells were quantified by real-time PCR.Results: The percentages of CD8+ nave and CD8(+) RTE cells and TREC levels were significantly lower in cancer patients than in controls (p=0.003, p=0.004, p=0.031, respectively). Telomere lengths in peripheral blood cells were significantly shorter in cancer patients than in controls (p=0.046) and did not correlate with age in patients, whereas it did in controls (r=-0.354, p=0.031). Short telomere (