Tumor necrosis factor receptor 1 expression and early spontaneous abortion
Tumor necrosis factor receptor 1 expression and early spontaneous abortion
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DOI：
10.1016/j.ijgo.2004.08.020
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发表时间：
2005-01-01
影响因子：
3.8
通讯作者：
Li, X
中科院分区：
文献类型：
--
作者：
Yu, XW;Yan, CF;Li, X
目的：比较不明原因早期自然流产（UESA）与正常妊娠妇女肿瘤坏死因子受体1（TNFR 1）蛋白表达的差异。方法：采用前瞻性研究方法，对62例子宫内膜异位症患者和60例正常妊娠妇女进行研究。采用流式细胞术和免疫组化法检测蜕膜组织中TNFR 1的表达，ELISA法检测血清中可溶性TNFR 1的表达。所得数据的统计分析采用学生t检验、Fisher精确检验和非参数Wilcoxon检验。结果：蜕膜组织中肿瘤坏死因子受体1（mTNFR 1）阳性细胞百分率。UESA组和正常妊娠组分别为16.42+/-7.1和12.47+/-5.3（p
Objectives: To compare tumor necrosis factor receptor 1 (TNFR1) protein expression in women with unexplained early spontaneous abortion (UESA) and normal pregnancy. Methods: In a prospective study, 62 women with UESA and 60 with normal pregnancy were studied. Decidual membrane TNFR1 was detected by flow cytometry and immunohistochemistry, and serum soluble TNFR1 were by ELISA. Statistical analyses of resulting data employed the student's t test, the Fisher's Exact, and the nonparametric Wilcoxon test. Results: The percentage of membrane tumor necrosis factor receptor 1 (mTNFR1) positive decidual. cells was 16.42+/-7.1 for women with UESA and 12.47+/-5.3 for women with normal pregnancy (p