Saliva as a diagnostic tool for periodontal disease: current state and future directions
Saliva as a diagnostic tool for periodontal disease: current state and future directions
复制标题
DOI：
10.1111/j.1600-0757.2008.00288.x
复制
发表时间：
2009-01-01
影响因子：
18.6
通讯作者：
Wong, David T.
中科院分区：
文献类型：
--
作者：
Giannobile, William V.;Beikler, Thomas;Wong, David T.
在牙周学和种植牙科学中，传统的临床标准往往不足以确定活动性疾病的部位，不足以定量监测治疗反应或衡量未来疾病进展的易感性程度。唾液作为口腔和全身健康的一面镜子，是临床相关信息的宝贵来源，因为它包含针对牙周/种植体周围疾病独特生理方面的生物标记物，这些生物标记物组成的定性变化可以通过识别疾病易感性增强的患者、确定活动性疾病的部位、预测未来有活动性疾病的部位和/或作为监测治疗效果的替代终点而具有诊断价值。虽然唾液的诊断价值已经被认识到一段时间(50，51)，并在唾液中发现了潜在的牙周/种植周疾病的生物标志物(39，67，74)，但迄今为止进行的大多数工作都未能为临床医生提供可靠的辅助手段。然而，更复杂的分析技术的可用性使人有理由乐观地认为，唾液最终将成为更精确的治疗计划所需的工具。
In periodontics and implant dentistry, traditional clinical criteria are often insufficient for determining sites of active disease, for monitoring quantitatively the response to therapy or for measuring the degree of susceptibility to future disease progression. Saliva as a mirror of oral and systemic health is a valuable source for clinically relevant information because it contains biomarkers specific for the unique physiological aspects of periodontal/periimplant disease, and qualitative changes in the composition of these biomarkers could have diagnostic value by identifying patients with enhanced disease susceptibility, identifying sites with active disease, predicting sites that will have active disease in the future and/or serving as surrogate end points for monitoring the effectiveness of therapy. Although the diagnostic value of saliva has been recognized for some time (50, 51) and potential biomarkers of periodontal/peri-implant disease have been identified in saliva (39, 67, 74), most work carried out to date has failed to provide reliable aids to the clinician. However, the availability of more sophisticated analytic techniques give cause for optimism that saliva will eventually become the tool needed for more precise treatment planning.