Transcriptional control of human gametogenesis.
Transcriptional control of human gametogenesis.
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DOI：
10.1093/humupd/dmac002
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发表时间：
2022-05-02
影响因子：
13.3
通讯作者：
中科院分区：
文献类型：
--
作者：
配子发生的途径包括精细的细胞特化，伴随着基因组内容的精确划分，以产生完全成熟的精子和卵母细胞。转录因子是一类重要的分子，其在配子发生中起作用以调节内在基因表达程序，在指定（或确定）生殖细胞命运中起重要作用，并协助引导生殖细胞的完全成熟和维持其群体。此外，为了在体外加强或重定向细胞命运，最常被诱导、过表达或激活的是转录因子。许多评论都集中在配子发生的分子发育和遗传学，在体内和体外，在模式生物和人类，包括最近的几个全面的评论：在这里，我们特别关注转录因子的作用。干细胞生物学和多组学研究的最新进展使人们能够更深入地研究人类生殖发育的独特转录机制。此外，随着方法的不断改进，生殖细胞的体外分化可以为强大的功能获得和丧失遗传分析提供平台。这些分析描绘了独特的和共享的人类生殖细胞转录网络组件，与体细胞谱系特异性和多能性转录因子一起，在从多能干细胞到配子的转变中发挥作用。这一宏大的主题综述为人类不育和生殖疾病提供了额外的见解，这些疾病主要与转录因子网络的缺陷有关，因此可能有助于开发不孕症的新治疗方法。
The pathways of gametogenesis encompass elaborate cellular specialization accompanied by precise partitioning of the genome content in order to produce fully matured spermatozoa and oocytes. Transcription factors are an important class of molecules that function in gametogenesis to regulate intrinsic gene expression programs, play essential roles in specifying (or determining) germ cell fate and assist in guiding full maturation of germ cells and maintenance of their populations. Moreover, in order to reinforce or redirect cell fate in vitro, it is transcription factors that are most frequently induced, over-expressed or activated. Many reviews have focused on the molecular development and genetics of gametogenesis, in vivo and in vitro, in model organisms and in humans, including several recent comprehensive reviews: here, we focus specifically on the role of transcription factors. Recent advances in stem cell biology and multi-omic studies have enabled deeper investigation into the unique transcriptional mechanisms of human reproductive development. Moreover, as methods continually improve, in vitro differentiation of germ cells can provide the platform for robust gain- and loss-of-function genetic analyses. These analyses are delineating unique and shared human germ cell transcriptional network components that, together with somatic lineage specifiers and pluripotency transcription factors, function in transitions from pluripotent stem cells to gametes. This grand theme review offers additional insight into human infertility and reproductive disorders that are linked predominantly to defects in the transcription factor networks and thus may potentially contribute to the development of novel treatments for infertility.
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DOI：
10.1093/humrep/deab192
发表时间：
2021-10-18
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Bestetti I;Barbieri C;Sironi A;Specchia V;Yatsenko SA;De Donno MD;Caslini C;Gentilini D;Crippa M;Larizza L;Marozzi A;Rajkovic A;Toniolo D;Bozzetti MP;Finelli P
通讯作者：
Finelli P
DOI：
10.1146/annurev-genom-091212-153417
发表时间：
2013
影响因子：
8.7
作者：
Baxter RM;Vilain E
通讯作者：
Vilain E
影响因子：
4.1
作者：
Buonocore, Federica;Clifford-Mobley, Oliver;Achermann, John C.
通讯作者：
Achermann, John C.
影响因子：
56.9
作者：
Bowles, J;Knight, D;Koopman, P
通讯作者：
Koopman, P
影响因子：
4
作者：
Ayhan, Ozgecan;Balkan, Mahmut;Tolun, Aslihan
通讯作者：
Tolun, Aslihan