COVID-19 -Tuberculosis interactions: When dark forces collide.
COVID-19 -Tuberculosis interactions: When dark forces collide.
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DOI：
10.1016/j.ijtb.2020.07.003
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发表时间：
2020-12-01
期刊：
影响因子：
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通讯作者：
Sara Raju, Reyma
中科院分区：
文献类型：
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作者：
Udwadia, Zarir F;Vora, Agam;Sara Raju, Reyma
在过去的5个月里，SARS-2大流行以惊人的速度传播，与另一种更古老、更被忽视的空气传播疾病--结核病--产生了几种协同效应。结核病患者不仅更容易感染SARS-CoV-2，而且一旦感染，也可能产生不良后果。更严重的新冠肺炎对那些从结核病康复但仍有肺功能受损的患者来说，其后遗症也可能是毁灭性的。这些疾病有着几乎相同的生物社会决定因素，如贫困、过度拥挤、糖尿病和污染，以及一些临床上的相似之处。新冠肺炎大流行的后果，以及我们在全球范围内对其做出的封锁，可能会对结核病的诊断和控制产生深远而持久的影响，可能导致2020至2025年间新增630万结核病病例，并在此期间额外导致140万结核病死亡。迫切需要制定新的解决办法，否则结核病控制目标将永远无法实现，甚至可能倒退5-8年。
The SARS-2 pandemic which has moved with frightening speed over the last 5 months has several synergies with another older, and far more neglected airborne disease, tuberculosis. Patients with tuberculosis are not only more likely to be infected by SARS-CoV-2 but also likely to have adverse outcomes once infected. The sequelae of more severe forms of COVID-19 in patients who have recovered from TB but have residual compromised lung function, are also likely to be devastating. These diseases share almost identical bio-social determinants like poverty, overcrowding, diabetes and pollution and some clinical similarities. The consequences of the COVID-19 pandemic, and our global response to it with lockdowns, are likely to leave a profound and long-lasting impact on TB diagnosis and control, potentially leading to an additional 6.3 million cases of TB between 2020 and 2025, and an additional 1.4 million TB deaths during this time. Novel solutions will need to be urgently devised or else TB control targets will never be met and indeed may be set back by 5-8 years.