Progressive multifocal leukoencephalopathy: diffusion-weighted imaging and pathological correlations
Progressive multifocal leukoencephalopathy: diffusion-weighted imaging and pathological correlations
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DOI：
10.1007/s00234-003-1115-9
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发表时间：
2004-01-01
期刊：
影响因子：
2.8
通讯作者：
Schiffer, D
中科院分区：
文献类型：
--
作者：
Bergui, M;Bradac, GB;Schiffer, D
我们检查了两个进行性多灶性白质脑病（PML）患者的MRI，包括扩散加权成像（DWI），并计算表观扩散系数（ADC）。1例患者的病理结果与MRI结果进行了对比。病变的ADC值和DWI表现不同，取决于疾病的分期。较新的病灶和较大病灶的前沿ADC值为正常至低，DWI上呈高信号。较老的病灶和大病灶中心的ADC值增加，呈低信号。DWI上的高信号和低ADC值标志着活动性感染和细胞肿胀的区域，将其与修复性胶质增生区域区分开来。
We examined MRI of two patients with progressive multifocal leukoencephalopathy (PML), including diffusion-weighted imaging (DWI), with calculation of apparent diffusion coefficients (ADC). The pathology findings of one patient were compared with those of MRI. The lesions had different ADC and DWI appearances, depending on the stage of the disease. Newer lesions and the advancing edge of large lesions had normal-to-low ADC and gave high signal on DWI. Older lesions and the centre of large lesions had increased ADC and gave low signal. High signal on DWI and low ADC mark the regions of active infection and cell swelling, distinguishing them from areas of reparative gliosis.