The linearity and selectivity of neuronal responses in awake visual cortex.
The linearity and selectivity of neuronal responses in awake visual cortex.
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DOI：
10.1167/9.9.12
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发表时间：
2009-08-25
影响因子：
1.8
通讯作者：
Alonso JM
中科院分区：
文献类型：
--
作者：
Chen Y;Anand S;Martinez-Conde S;Macknik SL;Bereshpolova Y;Swadlow HA;Alonso JM
初级视皮层（V1）中的神经元通常根据其响应线性进行分类：它们对漂移光栅的视觉响应类似于刺激的线性复制的程度。这一分类得到了以下发现的支持，即在麻醉动物的V1区神经元中，反应线性呈双峰分布。然而，最近的研究表明，这种双峰分布可能不反映两种神经元类型，但膜电位和锋电位输出之间的非线性关系。这些先前研究的一个主要局限性是，它们测量的是麻醉动物的反应线性，其中神经元膜电位和尖峰阈值之间的距离通过麻醉人为增加。在这里，我们测量了清醒大脑中的V1响应线性及其与神经元自发放电率的相关性，神经元自发放电率与膜电位和阈值之间的距离有关。我们的研究结果表明，响应线性双峰分布在清醒的V1，但它是不相关的自发放电率。相反，自发放电率与对刺激的反应选择性和反应潜伏期相关性最好。
Neurons in primary visual cortex (V1) are frequently classified based on their response linearity: the extent in which their visual responses to drifting gratings resemble a linear replica of the stimulus. This classification is supported by the finding that response linearity is bimodally distributed across neurons in area V1 of anesthetized animals. However, recent studies suggest that such bimodal distribution may not reflect two neuronal types but a nonlinear relationship between the membrane potential and the spike output. A main limitation of these previous studies is that they measured response linearity in anesthetized animals, where the distance between the neuronal membrane potential and spike threshold is artificially increased by anesthesia. Here, we measured V1 response linearity in the awake brain and its correlation with the neuronal spontaneous firing rate, which is related to the distance between membrane potential and threshold. Our results demonstrate that response linearity is bimodally distributed in awake V1 but that it is poorly correlated with spontaneous firing rate. In contrast, the spontaneous firing rate is best correlated to the response selectivity and response latency to stimuli.
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影响因子：
2.5
作者：
Crowder, N. A.;Van Kleef, J.;Ibbotson, M. R.
通讯作者：
Ibbotson, M. R.
影响因子：
2.5
作者：
Mata, ML;Ringach, DL
通讯作者：
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影响因子：
5.5
作者：
FERSTER, D;LINDSTROM, S
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影响因子：
1.9
作者：
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通讯作者：
Grosof, DH
DOI：
10.1073/pnas.110135097
发表时间：
2000-07-05
影响因子：
11.1
作者：
McLaughlin, D;Shapley, R;Wielaard, DJ
通讯作者：
Wielaard, DJ