Stereospecific modulation of tumorigenicity by opioid antagonists.
Stereospecific modulation of tumorigenicity by opioid antagonists.
复制标题
阿片类拮抗剂对致瘤性的立体特异性调节。
DOI：
10.1016/0014-2999(85)90350-4
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发表时间：
1985
影响因子：
5
通讯作者：
McLaughlin,PJ
中科院分区：
文献类型：
--
作者：
Zagon,IS;McLaughlin,PJ
确定了纳洛酮 (+) 和 (-) 异构体对改变接种 S20Y 神经母细胞瘤的 A/Jax 小鼠肿瘤反应的影响。每天皮下注射15 mg/kg (−)纳洛酮的小鼠肿瘤发生率提高71%，肿瘤出现时间延迟33%，存活时间延长28%。在对照受试者中接种神经母细胞瘤细胞后，13 天内肿瘤发病率达到 100%。给予 15 mg/kg (+)纳洛酮的动物在神经瘤形成的各个方面与对照受试者相当。这些结果表明阿片拮抗剂对神经癌发挥立体特异性作用，并进一步证明内源性阿片系统在神经致癌表达中发挥重要作用。
The effects of (+) and (−) isomers of naloxone in altering tumor response in A/Jax mice inoculated with S20Y neuroblastoma were determined. Mice given daily subcutaneous injections of 15 mg/kg (−)naloxone had a 71% tumor incidence, a 33% delay in the time before tumor appearance, and a 28% increase in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 13 days. Animals given 15 mg/kg (+)naloxone were comparable to control subjects in all aspects of neural neoplasia. These results show that opioid antagonists exert a stereospecific action on neural cancers, and provide further evidence that endogenous opioid systems play an important role in neuro-oncogenic expression.