Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China
Novel triple-reassortant H1N1 swine influenza viruses in pigs in Tianjin, Northern China
复制标题
中国北方天津猪群中的新型三重重组 H1N1 猪流感病毒。
DOI：
10.1016/j.vetmic.2015.12.006
复制
发表时间：
2016-02-01
影响因子：
3.3
通讯作者：
Yu, Hai
中科院分区：
文献类型：
--
作者：
Sun, Ying-Feng;Wang, Xiu-Hui;Yu, Hai
猪对人流感病毒和禽流感病毒都很敏感，因此被认为是通过重组产生大流行性流感病毒的混合容器。在这项研究中，我们首次报道了从中国北方天津的猪中分离出的三种新型三重组H1N1猪流感病毒的遗传分析。系统发育分析表明，这些新型病毒含有2009年H1N1大流行（PB2、PB1、PA和NP）、欧亚猪（HA、NA和M）和三重组猪（NS）谱系的基因。这表明2009年H1N1大流行猪流感病毒与欧亚猪流感病毒和三重组猪流感病毒在天津猪群中发生了重配，并产生了新病毒。此外，2009 - 2013年猪流感病毒监测中还分离到3株类人H1N1病毒、2株经典型猪H1N1病毒和2株欧亚型猪H1N1病毒，说明天津地区猪群中存在多种猪H1N1病毒遗传系共传播。新型三重组H1N1猪流感病毒的出现可能对人类健康构成潜在威胁，并强调进一步持续监测的重要性。(C) 2015 Elsevier B.V.版权所有
Pigs are susceptible to both human and avian influenza viruses and therefore have been proposed to be mixing vessels for the generation of pandemic influenza viruses through reassortment. In this study, for the first time, we report the isolation and genetic analyses of three novel triple-reassortant H1N1 swine influenza viruses from pigs in Tianjin, Northern China. Phylogenetic analysis showed that these novel viruses contained genes from the 2009 pandemic H1N1 (PB2, PB1, PA and NP), Eurasian swine (HA, NA and M) and triple-reassortant swine (NS) lineages. This indicated that the reassortment among the 2009 pandemic H1N1, Eurasian swine and triple-reassortant swine influenza viruses had taken place in pigs in Tianjin and resulted in the generation of new viruses. Furthermore, three human-like H1N1, two classical swine H1N1 and two Eurasian swine H1N1 viruses were also isolated during the swine influenza virus surveillance from 2009 to 2013, which indicated that multiple genetic lineages of swine H1N1 viruses were co-circulating in the swine population in Tianjin, China. The emergence of novel triple-reassortant H1N1 swine influenza viruses may be a potential threat to human health and emphasizes the importance of further continuous surveillance. (C) 2015 Elsevier B.V. All rights reserved.