IDENTIFICATION OF VAGAL SENSORY RECEPTORS IN THE RAT LUNG - ARE THERE SUBTYPES OF SLOWLY ADAPTING RECEPTORS
IDENTIFICATION OF VAGAL SENSORY RECEPTORS IN THE RAT LUNG - ARE THERE SUBTYPES OF SLOWLY ADAPTING RECEPTORS
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DOI：
10.1113/jphysiol.1993.sp019657
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发表时间：
1993-05-01
影响因子：
5.5
通讯作者：
PETERSON, DF
中科院分区：
文献类型：
--
作者：
BERGREN, DR;PETERSON, DF
1.本文研究了开胸大鼠左侧迷走神经传入纤维的肺感觉感受器的特性。这些受体的活动记录在接近正常呼吸的机械通气，以及在放气，逐步充气和恒压充气的肺。数据也从闭胸大鼠中收集并单独分析。94%的受体位于同侧肺或气道，其余位于对侧肺。慢适应受体（SARs）不仅是最常见的肺受体，而且其中21%在呼吸周期的放气阶段是完全或主要活性的。在开胸和闭胸大鼠中发现了放气单位。支配SAR的所有纤维的平均传导速度平均为29.7 m s-1.4。我们发现快速适应受体（RARs）在大鼠中非常罕见。他们的活动是稀疏和不规则的。支配RAR的纤维的传导速度平均为12.3 m s-1.5。在剩余的肺纤维群中，C纤维远比RAR丰富。他们被观察到有一个平均传导速度为2.1 m s-1，基本水平的活动，这是不规则的和一个高的压力阈值的激活，并通过静脉注射辣椒素刺激。大鼠的肺受体与其他物种中报道的受体之间存在显著差异。这些变化包括肺内SAR的大量存在，仅具有通缩调制和RAR的罕见性。我们还遇到了C纤维，以前没有被系统地描述在大鼠。
1. We studied the characteristics of pulmonary sensory receptors whose afferent fibres are in the left vagus nerve of opened-chest rats. The activity of these receptors was recorded during mechanical ventilation approximating eupnoea, as well as during deflation, stepwise inflations and constant-pressure inflations of the lungs. Data were also collected from closed-chest rats and analysed separately.2. Ninety-four per cent of receptors were located in the ipsilateral lung or airways with the remainder in the contralateral lung.3. Not only were slowly adapting receptors (SARs) the most a un ant pulmonary receptors but 21 % of them were either exclusively or predominantly active during the deflationary phase of the ventilatory cycle. Deflationary units were found in opened- and closed-chest rats. The average conduction velocity for all fibres innervating SARs averaged 29.7 m s-1.4. We found rapidly adapting receptors (RARs) to be extremely rare in the rat. Their activity was sparse and irregular. The conduction velocities of fibres innervating RARs averaged 12.3 m s-1.5. Far more abundant than RARs in the remaining population of pulmonary fibres were C fibres. They were observed to have an average conduction velocity of 2.1 m s-1, base-level activity which was irregular and a high pressure threshold of activation and were stimulated by intravenous capsaicin injection.6. Notable differences exist between pulmonary receptors in rats and those reported in other species. The variations include the abundant existence of intrapulmonary SARs with exclusively deflationary modulation and the rarity of RARs. We also encountered C fibres which have not previously been described systematically in the rat.