Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight
Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight
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DOI：
10.3945/ajcn.112.037325
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发表时间：
2013-02-01
影响因子：
7.1
通讯作者：
Mericq, Veronica
中科院分区：
文献类型：
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作者：
Corvalan, Camila;Uauy, Ricardo;Mericq, Veronica
背景：在低出生体重的女孩中，肥胖增加了肾上腺素过早分泌和代谢并发症的风险。然而，这种关联在正常出生体重儿童及其潜在介质中的一致性仍然未知。目的：目的是评估7岁时肥胖指标和硫酸脱氢表雄酮（DHEAS）之间的关联，并评估激素标记物对这些关联的作用。设计：我们评估了969名参与者（6.9岁; 48%为女孩;所有坦纳I）在生长和肥胖智利队列研究中，DHEAS与体重、BMI、腰围（WC）、腰高比、皮褶厚度和总脂肪百分比之间的关系（生物阻抗）并确定这些关联是否与胰岛素、胰岛素样生长因子I（IGF-I）和瘦素有关。我们还比较了DHEAS正常和高的非肥胖和肥胖儿童从0岁到7岁的BMI和身高增长结果：DHEAS浓度在女孩之间相似（30.3 +/- 1.86 μ g/dL）和男孩（29.4 +/- 1.73 μ g/dL）（P > 0.05）; 17.3%的儿童肥胖（BMI年龄z评分>= 2 SD）。肥胖指标与DHEAS呈正相关且相似[即，BMI，β标准化回归系数：0.23（95% CI：0.17，0.29）; WC，β标准化回归系数：0.23（95% CI：0.16，0.30）];这些相关性仅与IGF-I和瘦素部分相关。肥胖儿童患高DHEAS的风险是对照组的两倍（OR：2.16; 95% CI：1.51，3.09）; 7岁时，高DHEAS的肥胖儿童比对照组更胖，更中心性肥胖（P < 0.05），尽管他们以前的生长情况相似（P > 0.05）。结论：在正常出生体重儿童中，肥胖与7岁时DHEAS呈正相关。美国临床营养杂志2013;97：318-25。
Background: In low-birth-weight girls, obesity increases the risk of premature adrenarche and metabolic complications. However, the consistency of this association in normal-birth-weight children and its potential mediators remain unknown.Objectives: The objectives were to assess the associations between obesity indicators and dehydroepiandrosterone sulfate (DHEAS) at 7 y of age and to evaluate the role of hormonal markers on these associations.Design: We assessed in 969 participants (6.9 y; 48% girls; all Tanner I) in the Growth and Obesity Chilean Cohort Study the associations between DHEAS and weight, BMI, waist circumference (WC), waist-to-height ratio, skinfold thickness, and percentage total fat (bioimpedance) and determined whether these associations were related to insulin, insulin-like growth factor I (IGF-I), andleptin. We also compared BMI and height growth from 0 to 7 y of age in nonobese and obese children with normal and high DHEAS (>= 75th percentile) at 7 y.Results: DHEAS concentrations were similar between girls (30.3 +/- 1.86 mu g/dL) and boys (29.4 +/- 1.73 mu g/dL) (P > 0.05); 17.3% of children were obese (BMI-for-age z score >= 2 SD). Adiposity indicators were positively and similarly associated with DHEAS [ie, BMI, beta standardized regression coefficient: 0.23 (95% CI: 0.17, 0.29); WC, beta standardized regression coefficient: 0.23 (95% CI: 0.16, 0.30)]; these associations were only partially related to IGF-I and leptin. Obese children had twice the risk of high DHEAS (OR: 2.16; 95% CI: 1.51, 3.09); at 7 y, obese children with high DHEAS were fatter and more centrally obese than their counterparts (P < 0.05), although their previous growth was similar (P > 0.05). None of the results differed by sex (P > 0.05).Conclusion: In children of normal birth weight, obesity is positively associated with DHEAS at 7 y of age. Am J Clin Nutr 2013;97:318-25.