Extracellular modulation of BMP activity in patterning the dorsoventral axis
Extracellular modulation of BMP activity in patterning the dorsoventral axis
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DOI：
10.1002/bdrc.20079
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发表时间：
2006-09-01
影响因子：
2.1
通讯作者：
Mullins, Mary C.
中科院分区：
文献类型：
--
作者：
Little, Shawn C.;Mullins, Mary C.
通过骨形态发生蛋白（BMPs）的信号传导调节发育中的胚胎和胚后生命中大量不同的生物学过程。BMP信号的许多见解来自BMP信号梯度的研究，沿着沿着脊椎动物和无脊椎动物的胚胎背腹（DV）轴模式细胞命运。本文综述了近年来在DV图案领域的BMP信号，重点是细胞外调制的关键机制，在形成BMP信号梯度在果蝇，非洲爪蟾，斑马鱼。
Signaling via bone morphogenetic proteins (BMPs) regulates a vast array of diverse biological processes in the developing embryo and in postembryonic life. Many insights into BMP signaling derive from studies of the BMP signaling gradients that pattern cell fates along the embryonic dorsal-ventral (DV) axis of both vertebrates and invertebrates. This review examines recent developments in the field of DV patterning by BMP signaling, focusing on extracellular modulation as a key mechanism in the formation of BMP signaling gradients in Drosophila, Xenopus, and zebra-fish.