Impact of cannabidiol on the acute and psychotomimetic effects of smoked cannabis: naturalistic study
Impact of cannabidiol on the acute and psychotomimetic effects of smoked cannabis: naturalistic study
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DOI：
10.1192/bjp.bp.110.077503
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发表时间：
2010-10-01
影响因子：
10.5
通讯作者：
Curran, H. Valerie
中科院分区：
文献类型：
--
作者：
Morgan, Celia J. A.;Schafer, Grainne;Curran, H. Valerie
背景大麻的两种主要成分，大麻二酚和四氢大麻酚（THC），在实验室给药时，在精神和行为上都有相反的效果。街头大麻是已知的，含有不同水平的每个cannabinoid.Aims要研究如何不同水平的cannabidiol和THC有影响的药物在naturalistic setting.Method的急性效应大麻用户（n = 134）进行了测试7天间隔的记忆和拟精神症状的措施，一旦他们是药物免费的，一旦而急性中毒自己选择的熏大麻。使用前所未有的方法，从每个用户收集大麻样本（以及唾液）并分析大麻素水平。在大麻的最高和最低大麻二酚含量的基础上，两组个体进行了直接compared.Results组没有不同的THC含量的大麻，他们吸。与吸食大麻二酚含量低的大麻的个人在散文回忆方面的明显损害不同，吸食大麻二酚含量高的大麻的参与者没有表现出记忆障碍。大麻二酚的含量并没有影响拟精神病症状，这是在这两个群体中升高时intoxic.Conclusions大麻二酚在CB，受体的拮抗作用可能是负责其配置文件中熏大麻，衰减记忆损害效应的THC。在减少危害方面，应该让用户意识到与吸食低大麻二酚大麻品种（如“臭鼬”）相关的记忆障碍风险较高，并鼓励使用含有较高水平大麻二酚的品种。
Background The two main constituents of cannabis, cannabidiol and e-tetrahydrocannabinol (THC), have opposing effects both pharmacologically and behaviourally when administered in the laboratory. Street cannabis is known to contain varying levels of each cannabinoid.Aims To study how the varying levels of cannabidiol and THC have an impact on the acute effects of the drug in naturalistic settings.Method Cannabis users (n = 134) were tested 7 days apart on measures of memory and psychotomimetic symptoms, once while they were drug free and once while acutely intoxicated by their own chosen smoked cannabis. Using an unprecedented methodology, a sample of cannabis (as well as saliva) was collected from each user and analysed for levels of cannabinoids. On the basis of highest and lowest cannabidiol content of cannabis, two groups of individuals were directly compared.Results Groups did not differ in the THC content of the cannabis they smoked. Unlike the marked impairment in prose recall of individuals who smoked cannabis low in cannabidiol, participants smoking cannabis high in cannabidiol showed no memory impairment. Cannabidiol content did not affect psychotomimetic symptoms, which were elevated in both groups when intoxicated.Conclusions The antagonistic effects of cannabidiol at the CB, receptor are probably responsible for its profile in smoked cannabis, attenuating the memory-impairing effects of THC. In terms of harm reduction, users should be made aware of the higher risk of memory impairment associated with smoking low-cannabidiol strains of cannabis like 'skunk' and encouraged to use strains containing higher levels of cannabidiol.