Iodide-Ion-Catalyzed Carbon-Carbon Bond-Forming Cross-Dehydrogenative Coupling for the Synthesis of Indole Derivatives
Iodide-Ion-Catalyzed Carbon-Carbon Bond-Forming Cross-Dehydrogenative Coupling for the Synthesis of Indole Derivatives
复制标题
碘离子催化碳-碳键交叉脱氢偶联合成吲哚衍生物
DOI：
10.1002/ejoc.201201585
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发表时间：
2013
影响因子：
2.8
通讯作者：
Albert S. C. Chan
中科院分区：
文献类型：
--
作者：
Zhenhua Jia;Takashi Nagano;Xingshu Li;Albert S. C. Chan
将Bu4NI催化的分子内交叉脱氢偶联反应应用于1H-吲哚类化合物的合成。在nBu4NI和叔丁基氢过氧化氢(TBHP)的催化作用下，芳胺类化合物发生分子内氧化偶联反应，以较好的产率得到相应的1H-吲哚衍生物。本文还对~3H-吲哚的合成进行了初步研究。这是Bu4NiI催化的C-C键形成CDC反应的罕见例子。
ThenBu4NI‐catalyzed intramolecular cross‐dehydrogenative coupling (CDC) reaction has been applied to the synthesis of 1H‐indole derivatives. Intramolecular oxidative coupling ofN‐arylenamines proceeded in the presence of a catalytic amount ofnBu4NI andtert‐butyl hydroperoxide (TBHP) to afford the corresponding 1H‐indole derivatives in good‐to‐excellent yields. A preliminary study of the synthesis of 3H‐indole is also reported. This is a rare example of thenBu4NI‐catalyzed C–C bond‐forming CDC reaction.