Single-voxel proton MR spectroscopy in toluene abuse
Single-voxel proton MR spectroscopy in toluene abuse
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DOI：
10.1016/s0730-725x(03)00175-9
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发表时间：
2003-09-01
影响因子：
2.5
通讯作者：
Minareci, O
中科院分区：
文献类型：
--
作者：
Aydin, K;Sencer, S;Minareci, O
甲苯是一种有机溶剂，吸入后会引起中毒性脑病，表现为认知障碍、小脑和锥体外系症状。我们研究了22名甲苯滥用者和年龄匹配的对照组的头颅MR图像和单体素MR波谱。滥用者的平均年龄为18.1岁，平均滥用时间为47个月。采用STEAM序列，TE值为30 ms，获取半卵圆中心、小脑和丘脑3个部位的MR波谱，计算N-乙酰天冬氨酸（NAA）/肌酸（Cr）、胆碱（Cho）/Cr、肌醇（mI）/Cr峰积分比。滥用者小脑和半卵圆中心的NAA/Cr显著低于对照组。甲苯滥用者半卵圆中心和小脑的mI/Cr高于对照组。丘脑的代谢物比例没有显着差异。小脑和半卵圆中心的NAA/Cr和mI/Cr比值与滥用时间有显著相关性。丘脑是一个神经元丰富的灰质结构，其NAA水平正常可能提示甲苯吸入对神经元无直接损伤。白色物质中NAA的选择性降低和mI的升高支持了轴索病变和胶质增生是慢性甲苯脑病的主要病理生理机制的理论。Cho/Cr比值升高不显著，表明甲苯吸入不会引起主动脱髓鞘。(C)2003年爱思唯尔公司All rights reserved.
Inhalation of toluene, which is an organic solvent, causes toxic encephalopathy characterized by cognitive impairment, cerebellar and extra-pyramidal symptoms. We studied cranial MR images and single-voxel MR spectroscopy of 22 toluene abusers and age-matched control subjects. The mean age of the abusers and mean duration of abuse were 18,1 years and 47 months, respectively. We got three MR spectra from the centrum semiovale, cerebellum and thalamus by using STEAM sequence with a TE value of 30 ms. N-acetyl aspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, myo-inositol (mI)/Cr peak integral ratios were calculated. NAA/Cr in the cerebellum and centrum semiovale of the abusers were significantly lower than those of the control subjects. mI/Cr in centrum semiovale and cerebellum were higher in toluene abusers. No significant difference was found in the metabolite ratios of the thalami. The association of NAA/Cr and mI/Cr ratios in cerebellum and centrum semiovale with the duration of abuse was significant. Normal level of NAA in thalamus, which was a neuron rich gray matter structure, might imply that toluene inhalation did not cause direct neuronal injury. Selective reduction of NAA and increased level of mI in white matter supported the theory of that axonopathy and gliosis were the main mechanisms of pathophysiology in chronic toluene encepholopathy. Insignificance of elevation of Cho/Cr ratios demonstrated that toluene inhalation did not cause active demyelination. (C) 2003 Elsevier Inc. All rights reserved.