Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets.
Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets.
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氧化应激与肝癌：病因学和治疗目标
DOI：
10.1155/2016/7891574
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发表时间：
2016
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Wang Z;Li Z;Ye Y;Xie L;Li W
越来越多的证据表明，氧化应激（OS）与肝细胞癌（HCC）的发生发展有关。然而，其机制在很大程度上仍然未知。通常情况下，当身体接收到来自内部或外部的任何危险信号时，就会发生OS，并进一步诱导DNA氧化损伤和异常蛋白质表达，使身体处于易受各种疾病（如癌症）发展的脆弱状态。有许多因素参与肝癌的发生，包括B肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染，酒精滥用和非酒精性脂肪性肝病（NAFLD）。OS与HCC的关系近年来受到越来越多的关注。因此，阐明OS在肝癌发生发展中的作用，对肝癌的防治具有重要意义。本文主要从细胞分子机制、肝癌的病因学和治疗靶点等方面对OS与肝癌发生发展的关系进行综述。
Accumulating evidence has indicated that oxidative stress (OS) is associated with the development of hepatocellular carcinoma (HCC). However, the mechanisms remain largely unknown. Normally, OS occurs when the body receives any danger signal—from either an internal or external source—and further induces DNA oxidative damage and abnormal protein expression, placing the body into a state of vulnerability to the development of various diseases such as cancer. There are many factors involved in liver carcinogenesis, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol abuse, and nonalcoholic fatty liver disease (NAFLD). The relationship between OS and HCC has recently been attracting increasing attention. Therefore, elucidation of the impact of OS on the development of liver carcinogenesis is very important for the prevention and treatment of liver cancer. This review focuses mainly on the relationship between OS and the development of HCC from the perspective of cellular and molecular mechanisms and the etiology and therapeutic targets of HCC.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
13.5
作者：
Aleksandrova, Krasimira;Boeing, Heiner;Noethlings, Ute;Jenab, Mazda;Fedirko, Veronika;Kaaks, Rudolf;Lukanova, Annekatrin;Trichopoulou, Antonia;Trichopoulos, Dimitrios;Boffetta, Paolo;Trepo, Elisabeth;Westhpal, Sabine;Duarte-Salles, Talita;Stepien, Magdalena;Overvad, Kim;Tjonneland, Anne;Halkjaer, Jytte;Boutron-Ruault, Marie-Christine;Dossus, Laure;Racine, Antoine;Lagiou, Pagona;Bamia, Christina;Benetou, Vassiliki;Agnoli, Claudia;Palli, Domenico;Panico, Salvatore;Tumino, Rosario;Vineis, Paolo;Bueno-De-Mesquita, Bas;Peeters, Petra H.;Gram, Inger Torhild;Lund, Eiliv;Weiderpass, Elisabete;Quiros, J. Ramon;Agudo, Antonio;Sanchez, Maria-Jose;Gavrila, Diana;Barricarte, Aurelio;Dorronsoro, Miren;Ohlsson, Bodil;Lindkvist, Bjoern;Johansson, Anders;Sund, Malin;Khaw, Kay-Tee;Wareham, Nicholas;Travis, Ruth C.;Riboli, Elio;Pischon, Tobias
通讯作者：
Pischon, Tobias
影响因子：
4.2
作者：
Cai, Xianbin;Hu, Xi;Jing, Xubin
通讯作者：
Jing, Xubin
影响因子：
10.3
作者：
Bao, Ying;Giovannucci, Edward L.;Wolpin, Brian M.
通讯作者：
Wolpin, Brian M.
影响因子：
3.7
作者：
Al-Gayyar, Mohammed M. H.;Abbas, Ahmed;Hamdan, Ahmed M.
通讯作者：
Hamdan, Ahmed M.