Midazolarn sedation increases fluctuation and synchrony of the resting brain BOLD signal
Midazolarn sedation increases fluctuation and synchrony of the resting brain BOLD signal
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DOI：
10.1016/j.mri.2005.02.009
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发表时间：
2005-05-01
影响因子：
2.5
通讯作者：
Tervonen, O
中科院分区：
文献类型：
--
作者：
Kiviniemi, VJ;Haanpää, H;Tervonen, O
在麻醉儿童患者中，功能性脑皮质的血氧水平依赖性（BOLD）磁共振信号以极低频（VLF）波动为主。与清醒的成年人相比，麻醉儿童的BOLD信号的时间同步性也较高。同步波动的起源可能与成熟、病理状态或成像中使用的麻醉有关。本研究控制了三个混杂变量中的两个（成熟和病理学）。在12名健康成人（年龄24 ± 1.5岁）中，在1.5 T下评估咪达唑仑（4 ± 0.8 mg）镇静对BOLD信号的影响。镇静后，听觉和视觉皮层的VLF波动功率和BOLD信号的时间同步性显著增加。快速傅立叶变换功率谱基线拟合参数的BOLD信号也被发现后镇静显着变化。结果表明，镇静后BOLD信号在功能脑区的VLF波动和时间同步性增加。(c)2005年爱思唯尔公司All rights reserved.
The blood oxygen level-dependent (BOLD) magnetic resonance signal of functional brain cortices is dominated by very low frequency (VLF) fluctuations in anesthetized child patients. The temporal synchrony of the BOLD signal is also higher in anesthetized children compared with awake adults. The origin of the synchronous fluctuations can be related to maturation, pathological status or the anesthesia used in the imaging. Two of the three confounding variables (maturation and pathology) were controlled in this study. The effect of midazolam (4 +/- 0.8 mg) sedation on the BOLD signal was assessed in 12 healthy adults (aged 24 +/- 1.5 years) at 1.5 T. The VLF fluctuation power and temporal synchrony of the BOLD signal increased significantly after the sedation in the auditory and visual cortices. The fast Fourier transformation power spectral baseline fit parameters of the BOLD signal were also found to change significantly after sedation. It is concluded that the VLF fluctuation and temporal synchrony of the BOLD signal become increased after sedation in functional brain regions. (c) 2005 Elsevier Inc. All rights reserved.