Syndecan Binding Protein (SDCBP) Is Overexpressed in Estrogen Receptor Negative Breast Cancers, and Is a Potential Promoter for Tumor Proliferation
Syndecan Binding Protein (SDCBP) Is Overexpressed in Estrogen Receptor Negative Breast Cancers, and Is a Potential Promoter for Tumor Proliferation
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Syndecan 结合蛋白 (SDCBP) 在雌激素受体阴性乳腺癌中过度表达，是肿瘤增殖的潜在促进剂
DOI：
10.1371/journal.pone.0060046
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发表时间：
2013-03-22
期刊：
影响因子：
3.7
通讯作者：
Fu, Li
中科院分区：
文献类型：
--
作者：
Qian, Xiao-Long;Li, Ya-Qing;Fu, Li
背景资料：多配体聚糖结合蛋白（Syndecan binding protein，SDCBP）是一种含有PDZ结构域的衔接蛋白，与恶性黑色素瘤等多种恶性肿瘤的致瘤性和转移有关。我们的研究旨在揭示SDCBP在乳腺癌（BCa）中的表达谱及其在肿瘤细胞增殖中的作用，然后探讨其在BCa.Methodology/主要结果的靶向治疗中的价值：我们首先通过免疫组化评估SDCBP在正常乳腺和BCa组织中的表达。然后，我们探索SDCBP在不同的BCa细胞系中的表达谱。通过构建SDCBP沉默的BCa细胞克隆，我们进一步通过细胞培养和体内致瘤性评估SDCBP抑制对肿瘤细胞的影响。SDCBP在BCa组织中的表达率为80.6%（n = 160），而在正常乳腺组织中的表达率为13%（n = 23）（P
Background: Syndecan binding protein (SDCBP), an adapter protein containing PDZ domains, contributes to the tumorigenicity and metastasis of many malignant tumors, such as malignant melanoma. Our study aimed in revealing the expression profile of SDCBP in breast cancer (BCa) and its role in tumor cell proliferation, and then exploring its value in the targeted treatment of BCa.Methodology/Principal Findings: We first evaluated the SDCBP expression by immunohistochemistry in normal breast and BCa tissues. Then we explored the expression profile of SDCBP in different BCa cell lines. By constructing SDCBP-silenced BCa cell clones, we further assessed the effects of SDCBP suppression on tumor cells in vitro by cell culture and in vivo by tumorigenicity. SDCBP expression was detected in 80.6% (n = 160) of BCa tissues, in contrast to its expression in 13% (n = 23) of normal breast tissues (P