Assessment of Subtle Changes in Diabetes-Associated Arteriosclerosis using Photoplethysmographic Pulse Wave from Index Finger
Assessment of Subtle Changes in Diabetes-Associated Arteriosclerosis using Photoplethysmographic Pulse Wave from Index Finger
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DOI：
10.1007/s10916-018-0901-1
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发表时间：
2018-03-01
影响因子：
5.3
通讯作者：
Sun, Cheuk-Kwan
中科院分区：
文献类型：
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作者：
Hsu, Po-Chun;Wu, Hsien-Tsai;Sun, Cheuk-Kwan
宏观和微循环的扭曲是糖尿病相关并发症的主要因素。本研究旨在探讨无创性光体积描记(PPG)波形参数在检测糖尿病引起的动脉僵硬改变中的有效性。于2009年7月至2010年10月共纳入94例中老年受试者，其中非糖尿病患者48例(第1组)，糖尿病患者46例(第2组)。获得了人口学(即年龄、性别)、人体测量(体重指数)、生化(如糖化血红蛋白浓度)和血流动力学(如收缩压、心率)参数。将从左手食指采集的PPG信号计算的波峰时间(CT)和波峰时间比(CTR)与6导ECGPWV系统获得的左手食指脉搏波速度(PWVinger)进行比较，以探讨两组之间的差异以及这些指标与受试者参数的关系。两组间仅CTR有显著差异(P<；0.005)。尽管CTR和CTR都与年龄相关，但只有CTR与血流动力学参数有显著相关性。CTR可以区分糖尿病患者和健康人，尽管常规PWV评估的动脉僵硬没有差异，突出了它对糖尿病相关动脉硬化的细微变化的优越敏感性。
Distortions in macro-and microcirculation are principal contributors to diabetes-associated complications. This study aimed at investigating the validity of applying non-invasive photoplethysmographic (PPG) waveform parameters in detecting diabetesinduced subtitle changes in arterial stiffness. Between July 2009 and October 2010, totally 94 middle-aged and elderly subjects were recruited including 48 without diabetes (Group 1) and 46 with the disease (Group 2). Demographic (i. e., age, gender), anthropometric (body-mass index), biochemical (i. e., glycated hemoglobin concentration), and hemodynamic (i. e., systolic blood pressure, heart rate) parameters were obtained. Crest time (CT) and crest time ratio (CTR) computed from PPG signals acquired from left index finger were compared with left index finger pulse wave velocity (PWVfinger) obtained from six-channel ECGPWV system to investigate the differences between the two groups and the associations of these indices with the parameters of testing subjects. Significant difference was only noted in CTR between the two groups (P < 0.005). Despite correlation of both CTand CTR with age, only CTR demonstrated significant associations with hemodynamic parameters. CTR could differentiate diabetic patients from healthy individuals despite absence of difference in arterial stiffness assessed by conventional PWV, highlighting its superior sensitivity to subtle changes in diabetes-associated arteriosclerosis.