Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues
Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues
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DOI：
10.1016/s0960-0760(00)00040-6
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发表时间：
2000-01-01
影响因子：
4.1
通讯作者：
Pasqualini, JR
中科院分区：
文献类型：
--
作者：
Chetrite, GS;Cortes-Prieto, J;Pasqualini, JR
In the present study, the concentrations of estrone (E-1), estradiol (E-2) and their sulfates (E1S and E2S), as well as the sulfatase and aromatase activities, were evaluated in post-menopausal patients with breast cancer. Comparative studies of the evaluation of these parameters were carried out in (a) tumor tissue, (b) areas surrounding the tumor, and (c) areas distant from the tumor (glandular tissue) which were considered as normal tissue. The levels (in pm/g; mean +/- SEM) were: for E-1 in the (a) area: 320 +/- 95; in (b): 232 +/- 86; and in (c): 203 +/- 71; for E-2 in the (a) area: 388 +/- 106; in (b): 224 +/- 48; and in (c): 172 +/- 80; for E1S in the (a) area: 454 +/- 110; in (b): 259 +/- 90; and in (c): 237 +/- 65; for E2S in the (a) area: 318 +/- 67; in (b): 261 +/- 72; and in (c): 232 +/- 75, respectively. The values of E1S and E-2 were significantly higher in the tumor tissue than in the area considered as normal. In all the tissues studied, the sulfatase activity was much higher than aromatase (130-200). In addition, the sulfatase levels were significantly higher in the peripheral and in the tumor tissue than in the area considered as normal. The levels of aromatase were significantly higher in tumoral than in normal tissue. The present data extend the "intracrine concept" for breast cancer tumors. The physiopathology and clinical significance as promoter parameters in breast cancer is to be explored. (C) 2000 Elsevier Science Ltd. All rights reserved.
