Daily auricular stimulation with capsaicin ointment improved cough reflex sensitivity in elderly patients with dysphagia: a pilot study
Daily auricular stimulation with capsaicin ointment improved cough reflex sensitivity in elderly patients with dysphagia: a pilot study
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每日耳部刺激辣椒素软膏可改善老年吞咽困难患者的咳嗽反射敏感性：一项初步研究
DOI：
10.1080/00016489.2020.1716993
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发表时间：
2020
影响因子：
1.4
通讯作者：
Takeda Noriaki
中科院分区：
文献类型：
--
作者：
Ohnishi Hiroki;Jinnouchi Osamu;Agawa Seiji;Kondo Eiji;Kawata Ikuji;Okamoto Hidehiko;Azuma Takahiro;Sato Go;Kitamura Yoshiaki;Abe Koji;Takeda Noriaki
背景：在我们之前的研究中，单一耳穴应用辣椒素软膏，而不是安慰剂，可以改善老年吞咽困难患者的咳嗽反射。目的/目的：在目前的研究中，我们研究了在相似的患者中，每天耳部应用辣椒素软膏是否继续改善咳嗽反射。材料与方法：用棉签将0.025%辣椒素软膏交替涂抹于各外耳道，每日1次，连续2周。在老年吞咽困难住院患者中，采用数字计分和柠檬酸吸入性咳嗽激发试验来评估电视内窥镜检查对咳嗽反射的敏感性。结果：每日耳穴涂抹辣椒素软膏2周后，喉镜下声门闭合评分和咳嗽反应明显改善，柠檬酸咳嗽阈值显著降低。患者每日应用辣椒素前后的内窥镜评分与柠檬酸咳嗽阈值之间存在显著相关性。结论：老年吞咽困难患者每日应用辣椒素软膏持续耳部刺激2周，可持续改善咳嗽反射敏感性。意义：每日使用辣椒素软膏进行耳部刺激是预防有误吸风险的老年人肺炎的安全有效的干预措施。
Background: In our previous study, a single auricular application of capsaicin ointment, but not placebo improved cough reflex in elderly patients with dysphagia. Aims/Objectives: In the present study, we examined whether daily auricular application of capsaicin ointment continued to improve cough reflex in similar patients. Material and Methods: With a cotton swab, 0.025% capsaicin ointment was applied in each external auditory canal alternately once a day for two weeks. The cough reflex sensitivity was evaluated on videoendoscopy using a numerical score and inhalation cough challenge test using citric acid in elderly dysphagic inpatients. Results: After daily auricular application of capsaicin ointment for two weeks, the endoscopic score of glottal closure and cough reflexes significantly improved, and the citric acid cough threshold significantly decreased. There was a significant correlation between the endoscopic score and the citric acid cough threshold before and after daily capsaicin application in the patients.Conclusions: Daily auricular stimulation with capsaicin ointment for two weeks continued to improve the cough reflex sensitivity in elderly patients with dysphagia. Significance: Daily auricular stimulation with capsaicin ointment would be a safe and effective intervention to prevent pneumonia in elderly with a risk of aspiration.