Prevalence of problem and pathological gambling in Parkinson's disease
Prevalence of problem and pathological gambling in Parkinson's disease
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DOI：
10.1007/s10899-008-9099-3
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发表时间：
2008-12-01
影响因子：
2.4
通讯作者：
el-Guebaly, Nady
中科院分区：
文献类型：
--
作者：
Crockford, David;Quickfall, Jeremy;el-Guebaly, Nady
在接受多巴胺激动剂治疗的帕金森病(PD)患者中发现了病理性赌博(PG)，这表明脑多巴胺能活动的失调可能导致赌博问题的发展。目前的研究是为了进一步确定问题和PG在PD患者中的患病率，确定任何临床相关因素，并确定精神疾病或药物使用的共同发病率是否导致问题和PG的患病率增加。采用加拿大问题赌博指数、酒精使用障碍识别测试、药物滥用筛查测试、贝克抑郁量表、贝克焦虑量表和简明精神状态检查结合图表检查，对140名连续招募的中、重度帕金森病患者进行了横断面调查，为期8个月。在年龄相当的样本中，帕金森病患者12个月的问题和PG患病率为9.3%，而在普通人群中为1.6%。帕金森病组中问题和PG的增加与多巴胺激动剂的使用和年龄较小有关，但与合并发病无关。大多数有问题和PG的人在被诊断为帕金森病并开始治疗后，他们的赌博增加。结果提示，脑多巴胺能活动参与了问题和PG的神经生物学基础。
Pathological gambling (PG) has been identified in patients with Parkinson's disease (PD) treated with dopamine agonists suggesting that dysregulation of brain dopaminergic activity may contribute to the development of gambling problems. The current study was undertaken to further establish the prevalence of problem and PG in patients with PD, identify any clinical correlates, and determine if psychiatric or substance use co-morbidity contributes to the increased prevalence of problem and PG. A cross-sectional survey of 140 serially recruited moderate to severe PD patients was undertaken utilizing the Canadian Problem Gambling Index, Alcohol Use Disorders Identification Test, Drug Abuse Screening Test, Beck Depression Inventory, Beck Anxiety Inventory, and Mini-Mental State Exam augmented by chart review, completed over an 8 month period. The 12 month prevalence of problem and PG in PD was 9.3% compared to 1.6% in the general population within a comparably aged sample. The increased prevalence of problem and PG in the PD group was related to dopamine agonist use and younger age, but not co-morbidity. Most subjects with problem and PG reported their gambling increased after being diagnosed with PD and starting treatment. The results suggest that brain dopaminergic activity is involved in the underlying neurobiology of problem and PG.