Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior.
Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior.
复制标题
反应要求和单位剂量改变了 GBR 12909 对可卡因维持行为的影响。
DOI：
10.1037//1064-1297.8.4.539
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Glowa,JR
中科院分区：
文献类型：
--
作者：
Stafford,D;Rice,KC;Lewis,DB;Glowa,JR
Previous studies found that GBR 12909 can decrease cocaine-maintained responding at doses that do not affect food-maintained responding. In this study, the effects of GBR 12909 (0.3–3.0 mg/kg) were further examined by varying the response requirement and unit dose of cocaine. Rhesus monkeys earned food or cocaine under a multiple fixed-ratio (FR) schedule. The FR for food was always 30, but the FR for cocaine was varied from 10–130 and the unit dose was varied from 5.6–56.0 μg/kg per injection. Doses of GBR 12909 were tested in an ascending order, for 5 consecutive sessions each. GBR 12909 selectively decreased cocaine maintained responding in all monkeys in at least 1 condition. These effects were enhanced with large response requirements and/or small unit doses. The results demonstrate that environmental variables can influence the selectivity of GBR 12909's effects and contribute to a growing debate concerning the evaluation of potential pharmacotherapies for drug abuse.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
滥用药物的神经化学：可卡因、伊博加因和替代安非他明。
影响因子：
5.2
作者：
S. Ali
通讯作者：
S. Ali