Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study
Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study
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DOI：
10.1093/eurheartj/eht043
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发表时间：
2013-04-01
影响因子：
39.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Yamagishi, Kazumasa;Iso, Hiroyasu;Tsugane, Shoichiro
虽然膳食饱和脂肪酸（SFA）被认为是致动脉粥样硬化的，但SFA摄入与中风和冠心病之间的关系仍有争议。在平均SFA摄入量低于西方人的日本人中，SFA摄入量与中风及其亚型的风险呈负相关，与冠心病呈正相关。基于日本公共卫生中心的前瞻性研究包括两个亚组：队列I，1995年4564岁，随访至2009年，队列II，1998年4574岁，随访至2007年。本报告共包括38 084名男子和43 847名妇女。在五分之一的膳食SFA中，研究了总卒中、缺血性卒中、脑实质内出血、蛛网膜下腔出血、心肌梗死和心源性猝死的风险比。我们发现SFA摄入量与总卒中发生率呈负相关[多变量风险比最高与最低五分位数的（95置信区间）0.77（0.650.93），趋势P 0.002]，实质内出血[0.61（0.430.86），趋势P 0.005]和缺血性卒中[0.84（0.671.06），趋势P 0.08]，主要是深部脑实质内出血[0.67（0.450.99），趋势P 0.04]和腔隙性脑梗死[0.75（0.53，1.07），趋势P 0.02]。我们还观察到SFA摄入量与心肌梗死之间存在正相关性[1.39（0.932.08），趋势P 0.046]，主要发生在男性中。在日本人群中，SFA摄入量与深部脑实质内出血和腔隙性梗死呈负相关，与心肌梗死呈正相关。
Although dietary saturated fatty acids (SFA) are considered atherogenic, associations between SFAs intake and stroke and coronary heart disease are still debated. We sought to test the hypothesis that SFA intake is associated inversely with risk of stroke and its subtypes and positively with coronary heart disease among Japanese, whose average SFA intake is lower than that of Westerners.The Japan Public Health Center-based prospective Study involves two subcohorts: Cohort I, aged 4564 in 1995 and followed-up through 2009, and Cohort II, aged 4574 in 1998 and followed-up through 2007. A total of 38 084 men and 43 847 women were included in this report. Hazards ratios for incident total stroke, ischaemic stroke, intraparhenchymal haemorrhage, subarachnoid haemorrhage, myocardial infarction, and sudden cardiac death across quintiles of dietary SFAs were examined. We found inverse associations between SFA intake and total stroke [multivariable hazard ratio (95 confidence interval) for the highest vs. lowest quintiles 0.77 (0.650.93), trend P 0.002], intraparenchymal haemorrhage [0.61 (0.430.86), P for trend 0.005], and ischaemic stroke [0.84 (0.671.06), trend P 0.08], primarily for deep intraparenchymal haemorrhage [0.67 (0.450.99), P for trend 0.04] and lacunar infarction [0.75 (0.53, 1.07), trend P 0.02]. We also observed a positive association between SFAs intake and myocardial infarction [1.39 (0.932.08), trend P 0.046] primarily among men. No associations were observed between SFAs intake and incidence of subarachnoid haemorrhage or sudden cardiac death.In this Japanese population, SFAs intake was inversely associated with deep intraparenchymal haemorrhage and lacunar infarction and positively associated with myocardial infarction.