Factors influencing the measurement of bioavailability, taking calcium as a model
Factors influencing the measurement of bioavailability, taking calcium as a model
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DOI：
10.1093/jn/131.4.1344s
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发表时间：
2001-04-01
影响因子：
4.2
通讯作者：
Heaney, RP
中科院分区：
文献类型：
--
作者：
Heaney, RP
对于不可代谢的补充营养素，生物利用度实际上等同于可吸收性。测量吸收性（平衡，药代动力学，示踪剂，尿增量，诱发的生理反应，并在体外）的方法进行了简要的特点和他们的效用比较。当源的内在标记是可能的，示踪剂方法通常是最准确和精确的，以及往往是最便宜的。简要介绍了各种方法测定终点的影响因素。这些因素包括来源因素如药物制剂，受试者因素如粘膜质量和吸收受试者的需求状态，以及共同摄入因素如其他食物或食物成分。大量的经验表明，吸收性很难从来源的化学知识，甚至从体外测试的结果来预测。因此，直接测量吸收能力是必不可少的，以确保监管机构和公众的来源提供了它的承诺。
For non-metabolizable supplemental nutrients, bioavailability is effectively equivalent to absorbability. Methods for measuring absorbability (balance, pharmacokinetic, tracer, urine increment, evoked physiological responses, and in vitro) are briefly characterized and their utility compared. When intrinsic labeling of a source is possible, tracer methods are generally the most accurate and precise, as well as often the least expensive. Factors influencing the measured end points of the various methods are described briefly. These include source factors such as pharmaceutic formulation, subject factors such as mucosal mass and the need status of the absorbing subject, and co-ingested factors such as other foods or food constituents. Extensive experience has shown that absorbability is difficult to predict from knowledge of the chemistry of the source, or even from the results of in vitro testing. Hence direct measurement of absorbability is essential to assure regulators and the general public that the source delivers what it promises.