[123I]β-CIT and SPECT in essential tremor and Parkinson's disease
[123I]β-CIT and SPECT in essential tremor and Parkinson's disease
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DOI：
10.1007/s007020050124
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Brücke, T
中科院分区：
文献类型：
--
作者：
Asenbaum, S;Pirker, W;Brücke, T
静息性和体位性震颤可出现在特发性震颤(ET)和帕金森病(PD)中。本研究的目的是探讨标记纹状体多巴胺转运体的可卡因衍生物[I-123]β-CIT和SPECT在鉴别这些疾病中的作用。方法：30例健康志愿者、32例ET患者和29例特发性帕金森病Hoehn/Yahr I期患者。计算纹状体的特异性非移位结合比(靶区/小脑-1)。结果：ET患者纹状体[I-123]β-CIT结合率在正常范围内，仅有一次升高至预期年龄控制值(+14.6%)。帕金森病患者不仅对患侧(壳核：-62%，尾状核：-35%)，而且同侧(壳核：-45%，尾状核：-22%)的特异性结合明显。结论：[I-123]β-CIT和SPECT纹状体多巴胺转运体显像可在疾病早期明确区分ET和PD。研究结果并未提示ET中存在多巴胺能黑质纹状体神经元的亚临床参与。
Resting and postural tremor may occur in essential tremor (ET) and Parkinson's disease (PD). The aim of the present study was to investigate the cocaine derivative [I-123]beta-CIT, which labels striatal dopamine transporters, and SPECT in differentiating these diseases.Methods: 30 healthy volunteers, 32 patients with ET and 29 patients with idiopathic PD of Hoehn/Yahr stage I were investigated. Specific over nondisplaceable binding ratios (target/cerebellum-1) were calculated for the striatum. the caudate nucleus and the putamen separately as well as a ratio putamen/caudate and the percent deviation of each patient's ratio from age-expected control values.Results: Striatal [I-123]beta-CIT binding ratios in ET were within normal ranges and showed only a discrete elevation to age-expected control values (+14.6%). In PD significantly reduced specific binding was evident not only contralaterally to the clinically affected side (putamen: -62%, caudate nucleus: -35%), but also ipsilaterally (putamen: -45%, caudate nucleus: -22%). All investigated parameters differed significantly between PD and controls and ET respectively.Conclusion: Imaging striatal dopamine transporters with [I-123]beta-CIT and SPECT could clearly distinguish between ET and PD in an early stage of the disease. Findings do not suggest a subclinical involvement of dopaminergic nigrostriatal neurons in ET.