Agarose Hydrogel Biomimetic Mineralization Model for the Regeneration of Enamel Prismlike Tissue
Agarose Hydrogel Biomimetic Mineralization Model for the Regeneration of Enamel Prismlike Tissue
复制标题
DOI：
10.1021/am4044823
复制
发表时间：
2014-01-08
影响因子：
9.5
通讯作者：
Chu, Chun Hung
中科院分区：
文献类型：
--
作者：
Cao, Ying;Mei, May Lei;Chu, Chun Hung
实验室研究表明，类牙釉质矿化组织可以再生并用于修复牙釉质损失。这对处理由牙齿侵蚀、磨耗和磨损引起的非龋齿牙齿脱落具有启示意义。在这项研究中，我们设计了一个水凝胶仿生矿化模型，用于具有棱柱结构的搪瓷样矿化组织的再生。采用扫描电子显微镜、x射线衍射、傅里叶变换红外光谱和纳米压痕硬度测试分析了模型在500ppm氟化物存在下在蚀刻牙釉质表面产生的矿化组织。生成的组织具有釉质棱柱状层，含有明确的六方羟基磷灰石晶体。再生牙釉质棱柱状组织的弹性模量和纳米硬度与天然牙釉质相近。因此，利用这种水凝胶仿生矿化模型进行牙釉质再生是治疗牙釉质损失的一种很有前途的方法。
Laboratory studies have demonstrated that enamel-like mineralized tissue can be regenerated and used to repair enamel loss. This has implications for the management of noncarious tooth loss resulting from dental erosion, attrition, and abrasion. In this study, we designed a hydrogel biomimetic mineralization model for the regeneration of enamel-like mineralized tissue with a prismatic structure. The mineralized tissue, which was generated by the model on an etched enamel surface in the presence of 500 ppm fluoride, was analyzed with scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and the nanoindentation hardness test. The generated tissue had enamel prismlike layers containing well-defined hexagonal hydroxyapatite crystals. The modulus of elasticity and the nanohardness of the regenerated enamel prismlike tissue were similar to those of natural enamel. Thus, the regeneration of enamel using this hydrogel biomimetic mineralization model is a promising approach for the management of enamel loss.